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Merck
CN
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文件

M7133

Sigma-Aldrich

4-甲基伞形酮硫酸盐 钾盐

sulfatase substrate

别名:

4-甲基伞形基硫酸钾

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About This Item

经验公式（希尔记法）:
C10H7KO6S
CAS号:
15220-11-8
分子量:
294.32
Beilstein:
3803203
EC 号:
239-272-2
MDL编号:
MFCD00016970
UNSPSC代码:
12352204
PubChem化学物质编号:
24897141
NACRES:
NA.32

质量水平

200

检测方案

≥99% (HPLC)

形式

powder

溶解性

water: 5 mg/mL, clear, colorless

荧光

λex 334 nm; λem 370 nm (pH 10.4)
λex 360 nm; λem 449 nm (Reaction products)

储存温度

−20°C

SMILES字符串

[K+].CC1=CC(=O)Oc2cc(OS([O-])(=O)=O)ccc12

InChI

1S/C10H8O6S.K/c1-6-4-10(11)15-9-5-7(2-3-8(6)9)16-17(12,13)14;/h2-5H,1H3,(H,12,13,14);/q;+1/p-1

InChI key

CSOCSPXOODWGLJ-UHFFFAOYSA-M

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一般描述

4-甲基伞形酮硫酸酯（4MUS）作为一种通用底物，是4-甲基伞形酮（4MU）的极性代谢物。

应用

4-甲基伞形酮硫酸酯钾盐已用作偶联荧光硫代转移酶测定的底物，以从3′-磷酸腺苷5′-磷酸盐再生3′-磷酸腺苷 5′-磷酸硫酸盐（PAPS），进而测定脑苷脂硫酸转移酶（CST）的酶活性。它还用作芳香基硫酸酯酶测定/4-甲基伞形酮硫酸酯（4-MUS）测定的底物，以测试蛋白磁珠复合体的酶活性。

生化/生理作用

4-甲基伞形酮硫酸酯（4MUS）能够进行脱硫，并参与4MU的无效循环。它可以用于测定多种硫酸酯酶的活性。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

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P M Edelbroek et al.
Journal of chromatography, 530(2), 347-358 (1990-09-14)
The anticoagulant phenprocoumon is mainly metabolized in humans to hydroxylated metabolites and their glucuronides. A method is described for the determination of phenprocoumon, 4'-hydroxyphenprocoumon, 6-hydroxyphenprocoumon, 7-hydroxyphenprocoumon, and their glucuronide and sulphate conjugates in human urine. Reversed-phase high-performance liquid chromatography is
Junichi Enokizono et al.
Drug metabolism and disposition: the biological fate of chemicals, 35(6), 922-928 (2007-03-14)
Breast cancer resistance protein (Bcrp/Abcg2) is a member of the ATP-binding cassette transporter family with the ability to transport a variety of sulfate conjugates. In the present study, the regional expression and activity of Bcrp and sulfotransferases (SULTs/Sults) were investigated
Anthony D Verderosa et al.
Scientific reports, 11(1), 1569-1569 (2021-01-17)
Antibiotics are failing fast, and the development pipeline remains alarmingly dry. New drug research and development is being urged by world health officials, with new antibacterials against multidrug-resistant Gram-negative pathogens as the highest priority. Antivirulence drugs, which inhibit bacterial pathogenicity
Lihua Wang-Eckhardt et al.
Cells, 10(12) (2021-12-25)
Sulfatide synthesis in the human renal cancer cell line SMKT-R3 was strongly inhibited in the presence of low µM concentrations of AG-205, a progesterone receptor membrane component 1 (PGRMC1) antagonist. This was also the case in Chinese hamster ovary (CHO)
A M Hassen et al.
Drug metabolism and disposition: the biological fate of chemicals, 24(7), 792-798 (1996-07-01)
The uptake of estrone sulfate (E1S; 1 to 400 microM), harmol sulfate (HS; 5 to 900 microM), and 4-methylumbelliferyl sulfate (4MUS; 5 to 1000 microM) was investigated in isolated rat hepatocytes in the presence or absence of inhibitors. Uptake of
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