product name
MPP 二盐酸盐 水合物, ≥97% (HPLC), white, powder
质量水平
检测方案
≥97% (HPLC)
形式
powder
储存条件
desiccated
颜色
white
溶解性
DMSO: soluble ≥20 mg/mL
SMILES字符串
Cl.Cl.Cc1c(nn(-c2ccc(O)cc2)c1-c3ccc(OCCN4CCCCC4)cc3)-c5ccc(O)cc5
InChI
1S/C29H31N3O3.2ClH/c1-21-28(22-5-11-25(33)12-6-22)30-32(24-9-13-26(34)14-10-24)29(21)23-7-15-27(16-8-23)35-20-19-31-17-3-2-4-18-31;;/h5-16,33-34H,2-4,17-20H2,1H3;2*1H
InChI key
FWDNPWVVRVSJQH-UHFFFAOYSA-N
一般描述
甲基-哌啶基-吡唑水合物（MPP）可由甲基-吡唑-三醇（MPT）（一种吡唑三醇）进行制备。
应用
MPP二盐酸盐水合物已在下列研究中被用作雌激素受体α拮抗剂：
- 用于人乳腺癌MCF-7细胞中
- 预处理子宫内膜 离体 器官培养（EVOC）
- 处理垂体以监测促黄体激素的分泌
生化/生理作用
MPP 二盐酸盐是一种特异性雌激素受体 α拮抗剂。
甲基-哌啶基-吡唑水合物（MPP）是一种雌激素受体α激动剂，其缺乏雌激素受体（ER）的配体功能β。它可促进水飞蓟宾诱导的人乳腺癌MCF-7细胞凋亡。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Fu Guangtao et al.
Frontiers in pharmacology, 12, 746391-746391 (2021-11-23)
Periprosthetic osteolysis is one of the major long-term complications following total joint replacement. Its cause is widely accepted to be wear particle-induced activation of inflammatory macrophages. No effective strategy for the prevention and treatment of periprosthetic osteolysis is yet available.
Nan Zheng et al.
Journal of pharmacological sciences, 128(3), 97-107 (2015-06-29)
The estrogen receptor alpha (ERα) has been proven to be one of the most important therapeutic targets in breast cancer over the last 30 years. Previous studies pointed out that a natural flavonoid, silibinin, induced apoptosis in human breast cancer
Julia Y H Liu et al.
General and comparative endocrinology, 272, 63-75 (2018-12-06)
Estrogen is well known to have a modulatory role on gastrointestinal tract, particularly through its interaction with nuclear estrogen receptors (ERs), alpha and beta (ERα/β). Recent functional studies also indicate that estrogen can activate a G-protein coupled estrogen receptor, GPR30
Hai-Bing Zhou et al.
Bioorganic & medicinal chemistry letters, 19(1), 108-110 (2008-11-19)
Methyl-piperidino-pyrazole (MPP), an estrogen receptor alpha (ERalpha)-selective antagonist we developed, has a basic side chain (BSC) attached to an ERalpha-selective agonist ligand, methyl-pyrazole-triol (MPT) through an ether linkage. To remove the possibility that metabolic cleavage of the BSC in MPP
Qinghai Meng et al.
Journal of advanced research, 28, 149-164 (2020-12-29)
Excessive inflammation and the pyroptosis of vascular endothelial cells caused by estrogen deficiency is one cause of atherosclerosis in post-menopausal women. Because autophagy is highly regulated by estrogen, we hypothesized that estrogen can reduce vascular endothelial cell pyroptosis through estrogen
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