产品名称
羟基积雪草苷 from Centella asiatica, ≥95% (HPLC)
SMILES string
O1C(C(C(C(C1C)O)O)O)OC2C(OC(C(C2O)O)OCC3OC(C(C(C3O)O)O)OC(=O)C54C(C(C(CC5)C)C)C6=CCC7C8(C(C(CC7(C6(CC4)C)C)O)C(C(C(C8)O)O)(CO)C)C)CO
InChI key
BNMGUJRJUUDLHW-UHFFFAOYSA-N
InChI
1S/C48H78O20/c1-19-10-11-48(13-12-46(6)22(28(48)20(19)2)8-9-27-44(4)14-24(52)39(61)45(5,18-50)38(44)23(51)15-47(27,46)7)43(62)68-42-35(59)32(56)30(54)26(66-42)17-63-40-36(60)33(57)37(25(16-49)65-40)67-41-34(58)31(55)29(53)21(3)64-41/h8,19-21,23-42,49-61H,9-18H2,1-7H3
assay
≥95% (HPLC)
form
powder
color
white to off-white
solubility
H2O: 1 mg/mL, clear, colorless
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
Quality Level
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Application
羟基积雪草苷已被用于研究其对小鼠巨噬细胞系（J774A.1）的细胞毒性作用。它还用作丝氨酸消旋酶 (SR) 的潜在抑制剂，用于体外和离体研究。
Biochem/physiol Actions
羟基积雪草苷具有广泛的生物学活性，包括抗炎、伤口愈合和抗氧化活性。据报道可通过抑制ERK、p38和NF-κB活性来抑制LPS诱导的TNF-α的产生。
羟基积雪草苷具有皮肤保湿特性。它是一种众所周知的胶原蛋白诱导剂，具有抗衰老和抗类风湿关节炎的作用。羟基积雪草苷还具有神经保护活性。
羟基积雪草苷是在积雪草（Gotu kola）中发现的一种三萜类化合物，积雪草是一种用于中药（TCM）、印度草药和非洲传统药物的草药。羟基积雪草苷具有广泛的生物学活性，包括抗炎、伤口愈合和抗氧化活性。据报道其可通过抑制ERK、p38和NF-κB活性来抑制LPS诱导的TNF-α的产生。
General description
羟基积雪草苷是从积雪草中提取的主要五环三萜皂苷化合物之一。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Wen-Jing Han et al.
Biomedical chromatography : BMC, 26(1), 26-32 (2011-03-18)
A rapid, sensitive and specific high-performance liquid chromatography/electrospray ionization mass spectrometric (LC-ESI-MS) method was developed and validated for the quantification of madecassoside, a major active constituent of Centella asiatica (L.) Urb. herbs, in rat plasma. With paeoniflorin as an internal
Jie Song et al.
Burns : journal of the International Society for Burn Injuries, 38(5), 677-684 (2012-03-01)
Keloid is a specific skin scar that expands beyond the boundaries of the original injury as it heals. The invasive nature of keloid and notable migratory activity of fibroblasts are a hallmark, which distinguishes keloids from other common scars. Madecassoside
Feng-Lun Zhang et al.
Biomedical chromatography : BMC, 22(2), 119-124 (2007-08-19)
A high-performance liquid chromatography method with evaporative light scattering detection was established for simultaneous determination of three major triterpenoid glycosides, i.e. asiaticoside, madecassoside and asiaticoside-B, in Centella asiatica extracts. The optimal chromatographic conditions were achieved on a COSMOSIL 5C(18)-MS-II column
Xueqing Shen et al.
Bioscience, biotechnology, and biochemistry, 83(3), 561-568 (2018-11-20)
Madecassoside is a major pentacyclic triterpene saponin from Centella asiatica with multiple pharmaceutical activities. In this study, we focused on its Propionibacterium acnes related anti-inflammation and skin hydration activities, both of which play important roles in skin homeostasis and barrier
Chang-Liang Xu et al.
Fitoterapia, 90, 112-118 (2013-07-24)
In this study, we investigated the neuroprotective effects of madecassoside, isolated from the Chinese medicinal herb Centella asiatica, in the rat model of early phase of parkinsonism. During intragastric administrations of madecassoside for 7 days, the rats were injected with
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