SMILES string
O1C(C(C(C(C1C)O)O)O)OC2C(OC(C(C2O)O)OCC3OC(C(C(C3O)O)O)OC(=O)C54C(C(C(CC5)C)C)C6=CCC7C8(C(C(CC7(C6(CC4)C)C)O)C(C(C(C8)O)O)(CO)C)C)CO
InChI key
BNMGUJRJUUDLHW-UHFFFAOYSA-N
InChI
1S/C48H78O20/c1-19-10-11-48(13-12-46(6)22(28(48)20(19)2)8-9-27-44(4)14-24(52)39(61)45(5,18-50)38(44)23(51)15-47(27,46)7)43(62)68-42-35(59)32(56)30(54)26(66-42)17-63-40-36(60)33(57)37(25(16-49)65-40)67-41-34(58)31(55)29(53)21(3)64-41/h8,19-21,23-42,49-61H,9-18H2,1-7H3
assay
≥95% (HPLC)
form
powder
color
white to off-white
solubility
H2O: 1 mg/mL, clear, colorless
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
2-8°C
Quality Level
General description
羟基积雪草苷是从积雪草中提取的主要五环三萜皂苷化合物之一。
Application
羟基积雪草苷已被用于研究其对小鼠巨噬细胞系（J774A.1）的细胞毒性作用。它还用作丝氨酸消旋酶 (SR) 的潜在抑制剂，用于体外和离体研究。
Biochem/physiol Actions
羟基积雪草苷具有广泛的生物学活性，包括抗炎、伤口愈合和抗氧化活性。据报道可通过抑制ERK、p38和NF-κB活性来抑制LPS诱导的TNF-α的产生。
羟基积雪草苷具有皮肤保湿特性。它是一种众所周知的胶原蛋白诱导剂，具有抗衰老和抗类风湿关节炎的作用。羟基积雪草苷还具有神经保护活性。
羟基积雪草苷是在积雪草（Gotu kola）中发现的一种三萜类化合物，积雪草是一种用于中药（TCM）、印度草药和非洲传统药物的草药。羟基积雪草苷具有广泛的生物学活性，包括抗炎、伤口愈合和抗氧化活性。据报道其可通过抑制ERK、p38和NF-κB活性来抑制LPS诱导的TNF-α的产生。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Guang-Xing Bian et al.
Biological & pharmaceutical bulletin, 31(3), 458-463 (2008-03-04)
Madecassoside (MA), one of the principle terpenoids in Centella asiatica, has shown protect effect on isolated rat hearts and isolated cardiomyocytes against reperfusion injury in our previous studies. The aim of this study is to investigate if MA also protected
Mingzhe Gao et al.
Se pu = Chinese journal of chromatography, 26(3), 362-365 (2008-08-30)
A high performance liquid chromatographic (HPLC) method was successfully used to separate asiaticoside and madecassoside from the extract of Centella asiatica (L.) Urb. The raw material containing 20% asiaticoside and 45% madecassoside was dissolved in methanol and used for the
Marek Haftek et al.
Experimental dermatology, 17(11), 946-952 (2008-05-28)
Skin ageing is a complex process determined by the genetic endowment of individual and environmental factors, such as sun exposure. The effects of skin ageing are mostly encountered in the superficial dermis and in the epidermis. We have previously demonstrated
Gui-Gui Li et al.
Yao xue xue bao = Acta pharmaceutica Sinica, 42(5), 475-480 (2007-08-21)
This study is to investigate if madecassoside can protect against myocardial reperfusion injury in rabbit heart in vivo. The ischemia reperfusion model was established. Left ventricular function and ECG were monitored at the ischemia and reperfusion period. The infarct areas
Guangtao Jia et al.
Journal of chromatography. A, 1193(1-2), 136-141 (2008-05-07)
In present study, the performance and separation characteristics of five macroporous resins for the enrichment and purification of asiaticoside and madecassoside from Centella asiatica extracts have been evaluated. The adsorption and desorption properties of total triterpene saponins (80% purity) on
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