M6940
Modafinil
≥98% (HPLC), Neuroprotective agent, solid
别名:
2-[(Diphenylmethyl)sulfinyl]acetamide
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关于此项目
经验公式（希尔记法）:
C15H15NO2S
化学文摘社编号:
分子量:
273.35
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
Modafinil, ≥98% (HPLC)
SMILES string
NC(=O)CS(=O)C(c1ccccc1)c2ccccc2
InChI
1S/C15H15NO2S/c16-14(17)11-19(18)15(12-7-3-1-4-8-12)13-9-5-2-6-10-13/h1-10,15H,11H2,(H2,16,17)
InChI key
YFGHCGITMMYXAQ-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
drug control
USDEA Schedule IV; Új pszichoaktív anyag / New psychoactive substance (Hungary), 78/2022. (XII. 28.) BM rendelet
color
white
solubility
DMSO: >10 mg/mL
originator
Teva
Quality Level
Gene Information
human ... SLC6A3(6531)
rat ... Slc6a3(24898)
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Biochem/physiol Actions
Modafinil is a central nervous system vigilance promoting agent, which posseses neuroprotective properties.
Features and Benefits
This compound was developed by Teva. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
此项目有
Kousuke Okimura et al.
Scientific reports, 11(1), 1843-1843 (2021-01-21)
At high latitudes, approximately 10% of people suffer from depression during the winter season, a phenomenon known as seasonal affective disorder (SAD). Shortened photoperiod and/or light intensity during winter season are risk factors for SAD, and bright light therapy is
Mariana Raineri et al.
PloS one, 7(10), e46599-e46599 (2012-10-12)
Methamphetamine is a drug of abuse that can cause neurotoxic damage in humans and animals. Modafinil, a wake-promoting compound approved for the treatment of sleeping disorders, is being prescribed off label for the treatment of methamphetamine dependence. The aim of
Derek Dunn et al.
Chemical biology & drug design, 81(3), 433-435 (2012-12-05)
Utilizing atypical wake-promoting agent modafinil (inactive in both rH(3) and hH(3) binding assays) as a launching pad, a series of sulfinyl- and sulfone-derived H(3) receptor inverse agonists were developed. Brain-permeable compound 27, a potent member of the series displayed excellent
Trends in on-label and off-label modafinil use in a nationally representative sample.
Renée A Peñaloza et al.
JAMA internal medicine, 173(8), 704-706 (2013-04-05)
Mei-Hong Qiu et al.
PloS one, 7(9), e45471-e45471 (2012-10-03)
We have previously shown that modafinil promotes wakefulness via dopamine receptor D(1) and D(2) receptors; however, the locus where dopamine acts has not been identified. We proposed that the nucleus accumbens (NAc) that receives the ventral tegmental area dopamine inputs
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