所有图片(3)
About This Item
经验公式（希尔记法）:
C5H7N3O · HCl
CAS号:
分子量:
161.59
EC 号:
MDL编号:
UNSPSC代码:
41106305
PubChem化学物质编号:
NACRES:
NA.51
推荐产品
生物来源
synthetic (organic)
质量水平
200
300
方案
≥99%
表单
crystalline powder
溶解性
water: 50 mg/mL, clear to slightly hazy, colorless
SMILES字符串
O=C1NC(N)=C(C)C=N1.[H]Cl
InChI
1S/C5H7N3O.ClH/c1-3-2-7-5(9)8-4(3)6;/h2H,1H3,(H3,6,7,8,9);1H
InChI key
ANWMULVRPAUPJT-UHFFFAOYSA-N
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应用
5-甲基胞嘧啶盐酸盐已被用作高效液相色谱（HPLC）法估计整体甲基化率的标准品。它还被用于高分辨率质谱分析。
5-甲基胞嘧啶被用于DNA甲基化过程（表观遗传学）的研究。
生化/生理作用
5-甲基胞嘧啶可介导基因表达、基因组印记和转位因子的抑制。它与翻译保真度和tRNA识别密切相关。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Tet proteins can convert 5-methylcytosine to 5-formylcytosine and 5-carboxylcytosine
Ito S, et al.
Science (New York, N.Y.), 333(6047), 1300-1303 (2011)
Absolute quantification of RNA or DNA using acid hydrolysis and mass spectrometry
Lowenthal MS, et al.
Analytical Chemistry, 6, 824-824 (2019)
Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA
Squires JE, et al.
Nucleic Acids Research, 40(11), 5023-5033 (2012)
Daniel Renciuk et al.
Nucleic acids research, 41(21), 9891-9900 (2013-08-22)
5-Hydroxymethylcytosine (5-hmC) was recently identified as a relatively frequent base in eukaryotic genomes. Its physiological function is still unclear, but it is supposed to serve as an intermediate in DNA de novo demethylation. Using X-ray diffraction, we solved five structures
Shinpei Yamaguchi et al.
Cell research, 23(3), 329-339 (2013-02-13)
Previous studies have revealed that mouse primordial germ cells (PGCs) undergo genome-wide DNA methylation reprogramming to reset the epigenome for totipotency. However, the precise 5-methylcytosine (5mC) dynamics and its relationship with the generation of 5-hydroxymethylcytosine (5hmC) are not clear. Here
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