M6159
α2-巨球蛋白 来源于人类血浆
BioUltra, ≥98% (SDS-PAGE)
别名:
α2-M
产品名称
α2-巨球蛋白 来源于人类血浆, BioUltra, ≥98% (SDS-PAGE)
biological source
human plasma
product line
BioUltra
assay
≥98% (SDS-PAGE)
form
lyophilized powder
mol wt
~720 kDa (four glycoprotein subunits)
composition
Protein, 15-30% biuret
technique(s)
inhibition assay: suitable
solubility
water: soluble 10 mg protein/mL, clear, colorless
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
human ... A2M(2)
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Analysis Note
对每个供体的血浆都进行了检测，发现 HIV-1/HIV-2 抗体、HCV 抗体和 HbSAg 抗体均为阴性。
Application
α2-巨球蛋白用于研究脂蛋白受体介导的血浆淀粉样蛋白-β 外周结合受损，这是阿尔茨海默′病前轻度认知障碍的早期生物标志物。它还用于控制补体激活的经典途径和 MBL 途径。
通过与蛋白酶形成复合物来抑制所有种类的内切蛋白酶。当蛋白酶切割巨球蛋白“诱饵”序列时，巨球蛋白重新排列并捕获蛋白酶。
Biochem/physiol Actions
α2-巨球蛋白在血浆和间质液中大量存在。蛋白酶-α2-M 平衡在介导炎症组织破坏中起重要作用。脓毒症、肺气肿、牙周炎、类风湿性关节炎和其他炎症性疾病患者的血清 α2-M 和蛋白酶-α2-M 复合物水平升高，而 α2-M 的氧化失活可能导致炎症期间的组织破坏。
α2-巨球蛋白（α2M）是一种多功能蛋白，是一种广谱蛋白酶抑制剂。α2M 是一种大的同型四聚体糖蛋白（720 kDa），由二硫键连接的二聚体连接，二聚体通过非共价相互作用形成四级结构。α2M 存在于正常血浆中，浓度为 220-230 mg/dl，占总血浆蛋白的 3-5%。
脓毒症、肺气肿、牙周炎、类风湿性关节炎和其他炎症性疾病患者的血清 α2-巨球蛋白（α2-M）和蛋白酶-α2-M 复合物水平升高。推测 α2-M 的氧化失活有助于炎症中的组织破坏。
Packaging
包装尺寸基于蛋白质含量
Physical form
从 0.02 M Tris、0.13 M 甘氨酸、pH 8.0 和 0.08 M 海藻糖中冻干
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
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R P Swenson et al.
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S V Petersen et al.
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木瓜蛋白酶是肽酶C1家族的一种半胱氨酸蛋白酶。它由单一多肽链组成，含有三个二硫键和一个酶活性所必需的巯基。
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