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应用
α2-巨球蛋白用于研究脂蛋白受体介导的血浆淀粉样蛋白-β 外周结合受损，这是阿尔茨海默′病前轻度认知障碍的早期生物标志物。它还用于控制补体激活的经典途径和 MBL 途径。
通过与蛋白酶形成复合物来抑制所有种类的内切蛋白酶。当蛋白酶切割巨球蛋白“诱饵”序列时，巨球蛋白重新排列并捕获蛋白酶。
生化/生理作用
α2-巨球蛋白在血浆和间质液中大量存在。蛋白酶-α2-M 平衡在介导炎症组织破坏中起重要作用。脓毒症、肺气肿、牙周炎、类风湿性关节炎和其他炎症性疾病患者的血清 α2-M 和蛋白酶-α2-M 复合物水平升高，而 α2-M 的氧化失活可能导致炎症期间的组织破坏。
α2-巨球蛋白（α2M）是一种多功能蛋白，是一种广谱蛋白酶抑制剂。α2M 是一种大的同型四聚体糖蛋白（720 kDa），由二硫键连接的二聚体连接，二聚体通过非共价相互作用形成四级结构。α2M 存在于正常血浆中，浓度为 220-230 mg/dl，占总血浆蛋白的 3-5%。
包装
包装尺寸基于蛋白质含量
外形
从 0.02 M Tris、0.13 M 甘氨酸、pH 8.0 和 0.08 M 海藻糖中冻干
分析说明
对每个供体的血浆都进行了检测，发现 HIV-1/HIV-2 抗体、HCV 抗体和 HbSAg 抗体均为阴性。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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