所有图片(1)
About This Item
经验公式（希尔记法）:
C4H5NOS · HCl
CAS号:
分子量:
151.61
Beilstein:
3993054
EC 号:
MDL编号:
UNSPSC代码:
51102829
PubChem化学物质编号:
NACRES:
NA.76
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一般描述
2-甲基-4-异噻唑啉-3-酮盐酸盐（MIT，甲基异噻唑啉酮）是合成异噻唑啉酮的衍生物。
应用
甲基异噻唑啉酮(MIT)已用于：
- 研究MIT作为细胞毒性物质，对支气管上皮细胞(BEAS-2B)和的影响，及在凋亡性细胞死亡中的作用
- 研究酪氨酸磷酸化对神经轴突和树突发育过程中粘着斑激酶(FAK)活性的影响
生化/生理作用
2-甲基-4-异噻唑啉-3-酮盐酸盐(MIT)是皮肤致敏物，会引起接触性皮炎和过敏。它在化妆品行业中广泛用作防腐剂。甲基异噻唑啉酮是一种神经毒素，过久暴露可能会引起神经元细胞死亡和神经突生长抑制。
警示用语：
Danger
危险分类
Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A - Skin Sens. 1
补充剂危害
储存分类代码
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges
从最新的版本中选择一种：
分析证书(COA)
Lot/Batch Number
Zhenzhen Wang et al.
Biomaterials, 113, 145-157 (2016-11-07)
As common reactive oxygen species, H2O2 is widely used for bacterial inactivation and wound disinfection. However, the concentrations used are always higher than physiological levels, which frequently result in potential toxicity to healthy tissue and even delay wound healing. Here
Siamak Javanbakht et al.
Materials science & engineering. C, Materials for biological applications, 96, 302-309 (2019-01-05)
In compression with the intravenous administration, oral delivery most commonly used due to the non-invasive nature and the fact that avoids patient pain and discomfort. By consideration this aim, ibuprofen as a model drug was loaded into two-dimensional tunnels and
Shen Du et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 22(17), 7408-7416 (2002-08-28)
Neurodegenerative disorders in humans may be triggered or exacerbated by exposure to occupational or environmental agents. Here, we show that a brief exposure to methylisothiazolinone, a widely used industrial and household biocide, is highly toxic to cultured neurons but not
Zhengxi Wei et al.
Toxicology letters, 338, 67-77 (2020-12-09)
Chemical-peptide conjugation is the molecular initiating event in skin sensitization. The OECD test guideline uses a high-performance liquid chromatography/ultraviolet (HPLC/UV) detection method to quantify chemical-peptide conjugation in a direct peptide reactivity assay (DPRA), which measures the depletion of two synthetic
Erol Capkin et al.
Chemosphere, 182, 720-729 (2017-05-23)
Triclosan (TRC), chloroxylenol (PCMX) and methylisothiazolinone (MIT) have been commonly used as an antimicrobial in soaps while borax (BRX) is used in household cleaning. After using these chemicals, they are washed down drains and getting into the aquatic ecosystem in
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