所有图片(1)
About This Item
经验公式（希尔记法）:
C20H30ClN5O4
CAS号:
分子量:
439.94
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
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质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: >10 mg/mL
H2O: insoluble
SMILES字符串
CNc1nc(Cl)nc2n(CC(COC(=O)C(C)(C)C)COC(=O)C(C)(C)C)cnc12
InChI
1S/C20H30ClN5O4/c1-19(2,3)16(27)29-9-12(10-30-17(28)20(4,5)6)8-26-11-23-13-14(22-7)24-18(21)25-15(13)26/h11-12H,8-10H2,1-7H3,(H,22,24,25)
InChI key
NASABYJQIYJDID-UHFFFAOYSA-N
生化/生理作用
P2Y12嘌呤受体拮抗剂。
P2Y12嘌呤受体的拮抗剂；在大鼠血小板中抑制ADP诱导的聚集，并在PGE1存在下拮抗大鼠和人血小板中ADP诱导的cAMP抑制，而不会影响转染的星形细胞瘤细胞中P2Y1受体诱导的PLC活性。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Bin Xu et al.
Journal of medicinal chemistry, 45(26), 5694-5709 (2002-12-13)
Activation by ADP of both P2Y(1) and P2Y(12) receptors in platelets contributes to platelet aggregation, and antagonists at these receptor subtypes have antithrombotic properties. In an earlier publication, we have characterized the SAR as P2Y(1) receptor antagonists of acyclic analogues
Josiane S Neves et al.
The Journal of allergy and clinical immunology, 125(2), 477-482 (2010-02-18)
Cysteinyl leukotrienes (cysLTs) are recognized to act via receptors (cysLTRs) expressed on cell surface plasma membranes. Agents that block cysLT(1) receptor (cysLT(1)R) are therapeutics for allergic disorders. Eosinophils contain multiple preformed proteins stored within their intracellular granules. Cell-free eosinophil granules
M G Zizzo et al.
British journal of pharmacology, 151(1), 73-81 (2007-03-14)
This study analysed the contribution of the purinergic system to enteric neurotransmission in the longitudinal muscle of mouse distal colon. Motor responses to exogenous ATP and to nerve stimulation in vitro were assessed as changes in isometric tension. ATP induced
Juan F Guarracino et al.
Neuroscience, 326, 31-44 (2016-04-09)
It is known that adenosine 5'-triphosphate (ATP) is released along with the neurotransmitter acetylcholine (ACh) from motor nerve terminals. At mammalian neuromuscular junctions (NMJs), we have previously demonstrated that ATP is able to decrease ACh secretion by activation of P2Y
Annachiara Mitrugno et al.
Platelets, 29(4), 383-394 (2017-05-20)
The release of ADP from platelet dense granules and its binding to platelet P2Y12 receptors is key to amplifying the initial hemostatic response and propagating thrombus formation. P2Y12 has thus emerged as a therapeutic target to safely and effectively prevent
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