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M5820

M344

Name: M344
Brand: SIGMA

≥98% (HPLC), HDAC inhibitor, powder

别名:

4-(Dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]-benzamide, MS 344, D237, N-Hydroxy-7-(4-dimethylaminobenzoyl)-aminoheptanamide

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关于此项目

经验公式（希尔记法）:

C₁₆H₂₅N₃O₃

化学文摘社编号:

251456-60-7

分子量:

307.39

UNSPSC Code:

12352200

PubChem Substance ID:

329818022

NACRES:

NA.77

MDL number:

MFCD03453554

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

Storage condition:

protect from light

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属性

产品名称

M344, ≥98% (HPLC), powder

Quality Level

100

assay

≥98% (HPLC)

form

powder

storage condition

protect from light

color

white to beige

solubility

DMSO: 10 mg/mL, clear

storage temp.

2-8°C

SMILES string

CN(C)c1ccc(cc1)C(=O)NCCCCCCC(=O)NO

InChI

1S/C16H25N3O3/c1-19(2)14-10-8-13(9-11-14)16(21)17-12-6-4-3-5-7-15(20)18-22/h8-11,22H,3-7,12H2,1-2H3,(H,17,21)(H,18,20)

InChI key

MXWDSZWTBOCWBK-UHFFFAOYSA-N

说明

Biochem/physiol Actions

M344 is a HDAC inhibitor and subtype selective for HDAC6 over HDAC1.

M344 is a HDAC inhibitor; subtype selective for HDAC6 over HDAC1. M344 inhibits HDAC (IC₅₀ = 100 nM) and also inhibits hyperacetylation of histone H4, terminal cell differentiation, transcription (γ-globin), and tumor cell death.

Features and Benefits

This compound is a featured product for Gene Regulation research. Click here to discover more featured Gene Regulation products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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商品

Discover Bioactive Small Molecules for Gene Regulation

We offer a variety of small molecule research tools, such as transcription factor modulators, inhibitors of chromatin modifying enzymes, and agonists/antagonists for target identification and validation in gene regulation research; a selection of these research tools is shown below.

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Jalila Chagraoui et al.

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Human hematopoietic stem cells (HSCs) exhibit attrition of their self-renewal capacity when cultured ex vivo, a process that is partially reversed upon treatment with epigenetic modifiers, most notably inhibitors of histone deacetylases (HDACs) or lysine-specific demethylase LSD1. A recent study showed

HDAC inhibitors suppress c-Jun/Fra-1-mediated proliferation through transcriptionally downregulating MKK7 and Raf1 in neuroblastoma cells.

Weiwen He et al.

Oncotarget, 7(6), 6727-6747 (2016-01-07)

Activator protein 1 (AP-1) is a transcriptional factor composed of the dimeric members of bZIP proteins, which are frequently deregulated in human cancer cells. In this study, we aimed to identify an oncogenic AP-1 dimer critical for the proliferation of

Functional analysis and in vitro correction of splicing FAH mutations causing tyrosinemia type I.

R Pérez-Carro et al.

Clinical genetics, 86(2), 167-171 (2013-07-31)

Hereditary tyrosinemia type I (HT1) is a rare disease caused by a deficiency of fumarylacetoacetate hydrolase (FAH) in the tyrosine catabolic pathway, resulting mainly in hepatic alterations due to accumulation of the toxic metabolites fumarylacetoacetate, maleylacetoacetate and succinylacetone. We have

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全球贸易项目编号

货号	GTIN
M5820-1MG	04061826273890
M5820-5MG	04061832645070