M5815
Monoclonal Anti-Myogenin antibody produced in mouse
clone F12B, purified immunoglobulin, buffered aqueous solution
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关于此项目
Conjugate:
unconjugated
Clone:
F12B, monoclonal
Application:
immunohistochemistry (formalin-fixed, paraffin-embedded sections)
immunoprecipitation (IP)
indirect ELISA
indirect immunofluorescence
western blot
immunoprecipitation (IP)
indirect ELISA
indirect immunofluorescence
western blot
Species reactivity:
mouse, rat, human
Citations:
16
Technique(s):
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1-2 μg/mL using rhabdomyosarcoma tissue sections
immunoprecipitation (IP): 2 μg using 1 mg protein lysate
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1 μg/mL
immunoprecipitation (IP): 2 μg using 1 mg protein lysate
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1 μg/mL
Uniprot accession no.:
产品名称
Monoclonal Anti-Myogenin antibody produced in mouse, clone F12B, purified immunoglobulin, buffered aqueous solution
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
F12B, monoclonal
form
buffered aqueous solution
mol wt
antigen 34 kDa
species reactivity
mouse, rat, human
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1-2 μg/mL using rhabdomyosarcoma tissue sections
immunoprecipitation (IP): 2 μg using 1 mg protein lysate
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1 μg/mL
isotype
IgG1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MYOG(4656)
mouse ... Myog(17928)
rat ... Myog(29148)
Application
Monoclonal Anti-Myogenin antibody produced in mouse has been used in immunohistochemistry, immunofluorescence and western blotting.
Biochem/physiol Actions
Myogenin acts as a biomarker in rhabdomyosarcoma (RMS). It has a role in developmental processes, such as hematopoiesis, neurogenesis, myogenesis, tumor cell invasion and metastasis.
Myogenin acts as a regulator during myoblast and skeletal muscle differentiation. It is considered as a definite marker for skeletal muscle differentiation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
General description
Myogenin belongs to the basic helix-loop-helix (bHLH) superfamily.
Myogenin is a transcription factor present in the nucleus. It possesses an amino-acid rich region and a helix-loop-helix structure. The gene encoding it is localized on human chromosome 1q31-41 and has three exons.
Immunogen
rat recombinant myogenin (amino acids 30-224).
Physical form
Solution in phosphate buffered saline containing 0.08% sodium azide.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
W Glenn McCluggage et al.
Histopathology, 63(4), 545-550 (2013-08-16)
Myogenin (myf4) is a nuclear transcription factor that is considered to be a sensitive and highly specific marker for skeletal muscle differentiation. Following the identification of focal strong nuclear staining with myogenin in two fibroepithelial polyps of the lower female
Calcium in the Regulation of Gene Expression
Encyclopedia of Toxicology, 126(9), 310-315 (2013)
Implantation of muscle satellite cells overexpressing myogenin improves denervated muscle atrophy in rats
Shen H, et al.
Brazilian journal of medical and biological research, 49(2) (2016)
H Shen et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 49(2), e5124-e5124 (2016-02-13)
This study evaluated the effect of muscle satellite cells (MSCs) overexpressing myogenin (MyoG) on denervated muscle atrophy. Rat MSCs were isolated and transfected with the MyoG-EGFP plasmid vector GV143. MyoG-transfected MSCs (MTMs) were transplanted into rat gastrocnemius muscles at 1
Ruhui Song et al.
Journal of cellular and molecular medicine, 25(18), 8645-8661 (2021-08-05)
Myocardin-related transcription factor-A/serum response factor (MRTF-A/SRF), a well-known transcriptional programme, has been proposed to play crucial roles in skeletal muscle development and function. However, whether MRTF-A participates in muscle regeneration and the molecular mechanisms are not completely understood. Here, we
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