推荐产品
生物来源
mouse
质量水平
偶联物
unconjugated
抗体形式
purified immunoglobulin
抗体产品类型
primary antibodies
克隆
F12B, monoclonal
表单
buffered aqueous solution
分子量
antigen 34 kDa
种属反应性
mouse, rat, human
技术
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1-2 μg/mL using rhabdomyosarcoma tissue sections
immunoprecipitation (IP): 2 μg using 1 mg protein lysate
indirect ELISA: suitable
indirect immunofluorescence: suitable
western blot: 1 μg/mL
同位素/亚型
IgG1
UniProt登记号
运输
wet ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MYOG(4656)
mouse ... Myog(17928)
rat ... Myog(29148)
一般描述
Myogenin belongs to the basic helix-loop-helix (bHLH) superfamily.
Myogenin is a transcription factor present in the nucleus. It possesses an amino-acid rich region and a helix-loop-helix structure. The gene encoding it is localized on human chromosome 1q31-41 and has three exons.
免疫原
rat recombinant myogenin (amino acids 30-224).
应用
Monoclonal Anti-Myogenin antibody produced in mouse has been used in immunohistochemistry, immunofluorescence and western blotting.
生化/生理作用
Myogenin acts as a biomarker in rhabdomyosarcoma (RMS). It has a role in developmental processes, such as hematopoiesis, neurogenesis, myogenesis, tumor cell invasion and metastasis.
Myogenin acts as a regulator during myoblast and skeletal muscle differentiation. It is considered as a definite marker for skeletal muscle differentiation.
外形
Solution in phosphate buffered saline containing 0.08% sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
WGK
nwg
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
W Glenn McCluggage et al.
Histopathology, 63(4), 545-550 (2013-08-16)
Myogenin (myf4) is a nuclear transcription factor that is considered to be a sensitive and highly specific marker for skeletal muscle differentiation. Following the identification of focal strong nuclear staining with myogenin in two fibroepithelial polyps of the lower female
Implantation of muscle satellite cells overexpressing myogenin improves denervated muscle atrophy in rats
Shen H, et al.
Brazilian journal of medical and biological research, 49(2) (2016)
H Shen et al.
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas, 49(2), e5124-e5124 (2016-02-13)
This study evaluated the effect of muscle satellite cells (MSCs) overexpressing myogenin (MyoG) on denervated muscle atrophy. Rat MSCs were isolated and transfected with the MyoG-EGFP plasmid vector GV143. MyoG-transfected MSCs (MTMs) were transplanted into rat gastrocnemius muscles at 1
Ruhui Song et al.
Journal of cellular and molecular medicine, 25(18), 8645-8661 (2021-08-05)
Myocardin-related transcription factor-A/serum response factor (MRTF-A/SRF), a well-known transcriptional programme, has been proposed to play crucial roles in skeletal muscle development and function. However, whether MRTF-A participates in muscle regeneration and the molecular mechanisms are not completely understood. Here, we
Dysregulated Myogenesis in Rhabdomyosarcoma
Current Topics in Developmental Biology, 126(9), 285-297 (2018)
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