M5625
甲萘醌
crystalline
别名:
2-甲基-1,4-萘醌, 维生素 K3
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关于此项目
经验公式（希尔记法）:
C11H8O2
化学文摘社编号:
分子量:
172.18
UNSPSC Code:
12352205
NACRES:
NA.79
PubChem Substance ID:
EC Number:
200-372-6
Beilstein/REAXYS Number:
1908453
MDL number:
产品名称
甲萘醌, crystalline
InChI key
MJVAVZPDRWSRRC-UHFFFAOYSA-N
InChI
1S/C11H8O2/c1-7-6-10(12)8-4-2-3-5-9(8)11(7)13/h2-6H,1H3
SMILES string
CC1=CC(=O)c2ccccc2C1=O
biological source
synthetic
assay
≥98.0% (HPLC)
form
crystalline
technique(s)
HPLC: suitable
color
faint green to green-yellow
mp
105-107 °C (lit.)
solubility
oil: soluble
storage temp.
room temp
Quality Level
Gene Information
human ... NQO1(1728)
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Application
甲萘醌用于产生活性氧（ROS），然后进行流式细胞术分析。它还用于微生物评估，例如检测苛求菌。
Biochem/physiol Actions
甲萘醌是一种芳香族多环酮。它是维生素K合成的前体。甲萘醌可转化为甲基萘醌-4（维生素K3的活性代谢产物）。甲萘醌通过无效的氧化还原循环诱导产生活性氧来介导细胞死亡。
甲萘醌（维生素K3）是1,4-萘醌的合成类似物，在2-位有一个甲基。甲萘醌是磷酸酶抑制剂，也是线粒体DNA聚合酶γ (pol γ)抑制剂。甲萘醌可用作氧化损伤（自由基生成剂）诱导剂。
signalword
Warning
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
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The Journal of biological chemistry, 257(20), 12419-12425 (1982-10-25)
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Loor G, et al.
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