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质量水平
检测方案
≥98% (HPLC)
形式
powder
颜色
off-white to tan
溶解性
DMSO: >25 mg/mL
储存温度
2-8°C
SMILES字符串
CCC(C)SSc1ncc[nH]1
InChI
1S/C7H12N2S2/c1-3-6(2)10-11-7-8-4-5-9-7/h4-6H,3H2,1-2H3,(H,8,9)
InChI key
BPBPYQWMFCTCNG-UHFFFAOYSA-N
应用
PX 12 已被用作硫氧还蛋白 1 抑制剂前列腺癌细胞系，以分析其对细胞活力的影响。也曾作为缺氧诱导因子 (HIF)-1α抑制剂处理 H2228 细胞。
生化/生理作用
PX-12 抑制硫氧还蛋白氧化还原系统和 HIF-1a 活性。PX 12 抑制缺氧诱导的 HIF-1a 转录活性（IC50 11 nM）和 HT29 和 MCF-7 肿瘤细胞的增殖（IC50 分别为 1.9 和 0.9 μM）。
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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