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M5255

霉酚酸

from Penicillium brevicompactum, ≥98% (HPLC), powder, IMP dehydrogenase inhibitor

别名:

6-（1,3-二氢-7-羟基-5-甲氧基-4-甲基-1-氧代异苯并呋喃-6-基）-4-甲基-4-己酸, 6-（4-羟基-6-甲氧基-7-甲基-3-氧代-5-酞酰）-4-甲基-4-己烯酸, NSC 129185

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关于此项目

经验公式（希尔记法）:
C17H20O6
化学文摘社编号:
24280-93-1
分子量:
320.34
NACRES:
NA.77
PubChem Substance ID:
24896987
UNSPSC Code:
12352106
EC Number:
246-119-3
MDL number:
MFCD00036814
Beilstein/REAXYS Number:
1295848
Assay:
≥98%
Quality level:
300
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产品名称

霉酚酸, ≥98%

biological source

Penicillium brevicompactum

Quality Level

300

assay

≥98%

color

white to yellow-white

mp

<143.0 °C

solubility

methanol: 49.00-51.00 mg/mL, clear, colorless to faintly yellow

mode of action

enzyme | inhibits

originator

Novartis

storage temp.

2-8°C

SMILES string

COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O

InChI

1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+

InChI key

HPNSFSBZBAHARI-RUDMXATFSA-N

Gene Information

human ... IMPDH1(3614), IMPDH2(3615)

Application

霉酚酸 (MPA) 由 青霉 (Penicillum brevi-compactum) 产生 ，是一种选择性的肌苷一磷酸脱氢酶抑制剂，从而抑制 T、B 淋巴细胞的 DNA 合成。在人淋巴和单核细胞系中，它还被证明可作为免疫抑制剂，以及单核细胞分化和凋亡的诱导剂。作为选择剂，MPA 用于表达大肠杆菌黄嘌呤-鸟嘌呤磷酸核糖转移酶基因的转染动物细胞，推荐使用 25μg/mL。

Biochem/physiol Actions

作用方式：本品通过抑制细胞因子诱导的一氧化氮生成，抑制嘌呤核苷酸的早期生物合成，并作为 IMP 脱氢酶的特异性抑制剂发挥作用。

Features and Benefits

该化合物由 Novartis 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表，请 点击这里 。

Preparation Note

麦考酚酸可溶于 50 mg/mL 甲醇，产生无色至淡黄色溶液，以及氯仿、二氯甲烷、乙醇和 1 N 氢氧化钠溶液。复溶后，建议通过 0.22 μm 过滤器灭菌m 孔径过滤器，分装，-20°C 冷冻。

Disclaimer

供应后，本品应在 2-8°C 干燥条件下储存，适当储存时可保持稳定 5 年。

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Danger

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Repr. 1B - STOT RE 1 Oral

target_organs

Immune system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000445541
0000445541
0000359869
0000359869
0000246560

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商品

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

相关内容

Data Sheet - M5255

Instructions

Guste Urbonaite et al.
Communications biology, 4(1), 822-822 (2021-07-02)
Stochastic gene expression leads to inherent variability in expression outcomes even in isogenic single-celled organisms grown in the same environment. The Drop-Seq technology facilitates transcriptomic studies of individual mammalian cells, and it has had transformative effects on the characterization of
Natacha S Ogando et al.
Transplant international : official journal of the European Society for Organ Transplantation, 35, 10369-10369 (2022-07-12)
Kidney transplant recipients (KTRs) are at increased risk for a more severe course of COVID-19, due to their pre-existing comorbidity and immunosuppression. Consensus protocols recommend lowering immunosuppression in KTRs with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but the
Ping Liu et al.
Current genetics, 66(4), 813-822 (2020-04-02)
Slowing down aging-associated accumulation of molecular damage or its prevention represents a promising therapeutic paradigm to combat aging-related disease and death. While several chemical compounds extend lifespan in model organisms, their mechanism of action is often unknown, reducing their therapeutic
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全球贸易项目编号

货号GTIN
M5255-50MG04061834059622
M5255-250MG04061834059615