跳转至内容
Merck
CN
所有图片(1)

主要文件

查看所有文档

安全信息

M5255

Sigma-Aldrich

霉酚酸

from Penicillium brevicompactum, ≥98% (HPLC), powder, IMP dehydrogenase inhibitor

别名:

6-（1,3-二氢-7-羟基-5-甲氧基-4-甲基-1-氧代异苯并呋喃-6-基）-4-甲基-4-己酸, 6-（4-羟基-6-甲氧基-7-甲基-3-氧代-5-酞酰）-4-甲基-4-己烯酸, NSC 129185

登录查看公司和协议定价
所有图片(1)

About This Item

经验公式（希尔记法）:
C17H20O6
CAS号:
24280-93-1
分子量:
320.34
Beilstein:
1295848
EC 号:
246-119-3
MDL编号:
MFCD00036814
UNSPSC代码:
12352106
PubChem化学物质编号:
24896987
NACRES:
NA.77

产品名称

霉酚酸, ≥98%

生物来源

Penicillium brevicompactum

质量水平

300

方案

≥98%

颜色

white to yellow-white

mp

<143.0 °C

溶解性

methanol: 49.00-51.00 mg/mL, clear, colorless to faintly yellow

作用机制

enzyme | inhibits

创始人

Novartis

储存温度

2-8°C

SMILES字符串

COc1c(C)c2COC(=O)c2c(O)c1C\C=C(/C)CCC(O)=O

InChI

1S/C17H20O6/c1-9(5-7-13(18)19)4-6-11-15(20)14-12(8-23-17(14)21)10(2)16(11)22-3/h4,20H,5-8H2,1-3H3,(H,18,19)/b9-4+

InChI key

HPNSFSBZBAHARI-RUDMXATFSA-N

基因信息

human ... IMPDH1(3614) , IMPDH2(3615)

正在寻找类似产品? 访问 产品对比指南

应用

霉酚酸 (MPA) 由 青霉 (Penicillum brevi-compactum) 产生 ，是一种选择性的肌苷一磷酸脱氢酶抑制剂，从而抑制 T、B 淋巴细胞的 DNA 合成。在人淋巴和单核细胞系中，它还被证明可作为免疫抑制剂，以及单核细胞分化和凋亡的诱导剂。作为选择剂，MPA 用于表达大肠杆菌黄嘌呤-鸟嘌呤磷酸核糖转移酶基因的转染动物细胞，推荐使用 25μg/mL。

生化/生理作用

作用方式：本品通过抑制细胞因子诱导的一氧化氮生成，抑制嘌呤核苷酸的早期生物合成，并作为 IMP 脱氢酶的特异性抑制剂发挥作用。

特点和优势

该化合物由 Novartis 开发。要浏览其他制药公司开发的化合物列表批准的药物/候选药物的列表，请 点击这里 。

注意

供应后，本品应在 2-8°C 干燥条件下储存，适当储存时可保持稳定 5 年。

制备说明

麦考酚酸可溶于 50 mg/mL 甲醇，产生无色至淡黄色溶液，以及氯仿、二氯甲烷、乙醇和 1 N 氢氧化钠溶液。复溶后，建议通过 0.22 μm 过滤器灭菌m 孔径过滤器，分装，-20°C 冷冻。

警示用语：

Danger

危险分类

Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Muta. 2 - Repr. 1B - STOT RE 1 Oral

靶器官

Immune system

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

从最新的版本中选择一种：

分析证书(COA)

Lot/Batch Number
0000359869
0000359869
0000246560
0000217836
0000217834

没有发现合适的版本？

如果您需要特殊版本，可通过批号或批次号查找具体证书。

搜索COA

已有该产品？

在文件库中查找您最近购买产品的文档。

访问文档库

Guste Urbonaite et al.
Communications biology, 4(1), 822-822 (2021-07-02)
Stochastic gene expression leads to inherent variability in expression outcomes even in isogenic single-celled organisms grown in the same environment. The Drop-Seq technology facilitates transcriptomic studies of individual mammalian cells, and it has had transformative effects on the characterization of
Natacha S Ogando et al.
Transplant international : official journal of the European Society for Organ Transplantation, 35, 10369-10369 (2022-07-12)
Kidney transplant recipients (KTRs) are at increased risk for a more severe course of COVID-19, due to their pre-existing comorbidity and immunosuppression. Consensus protocols recommend lowering immunosuppression in KTRs with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, but the
Ping Liu et al.
Current genetics, 66(4), 813-822 (2020-04-02)
Slowing down aging-associated accumulation of molecular damage or its prevention represents a promising therapeutic paradigm to combat aging-related disease and death. While several chemical compounds extend lifespan in model organisms, their mechanism of action is often unknown, reducing their therapeutic
Amy Tarangelo et al.
Life science alliance, 5(4) (2022-01-26)
Nucleotide synthesis is a metabolically demanding process essential for DNA replication and other processes in the cell. Several anticancer drugs that inhibit nucleotide metabolism induce apoptosis. How inhibition of nucleotide metabolism impacts non-apoptotic cell death is less clear. Here, we
Burkhard Tönshoff et al.
Transplantation reviews (Orlando, Fla.), 25(2), 78-89 (2011-04-02)
Mycophenolate mofetil (MMF) is widely used for maintenance immunosuppressive therapy in pediatric renal and heart transplant recipients. Children undergo developmental changes (ontogeny) of drug disposition, which may affect drug metabolism of the active compound mycophenolic acid (MPA). Therefore, a detailed
查看所有相关文献

商品

Bioactive Molecules for Immunology Research

Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.

我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.

联系技术服务部门