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质量水平
方案
≥98% (HPLC)
表单
lyophilized powder
储存条件
desiccated
技术
cell culture | embryo: suitable
颜色
white
溶解性
H2O: soluble
储存温度
−20°C
SMILES字符串
Cl.Cl.Cc1cccc(CCN2CCC(CC2)C(=O)c3ccc(NS(C)(=O)=O)cc3)n1
InChI
1S/C21H27N3O3S.2ClH/c1-16-4-3-5-19(22-16)12-15-24-13-10-18(11-14-24)21(25)17-6-8-20(9-7-17)23-28(2,26)27;;/h3-9,18,23H,10-15H2,1-2H3;2*1H
InChI key
ZQBNWMFBOSOOLX-UHFFFAOYSA-N
相关类别
应用
E-4031 已用作:
- 人类诱导多能干细胞衍生的心肌细胞(hiPSC-CMs)中的人类ether-a-go-go基因(hERG)阻断剂
- 长QT综合征(LQTS)诱导的多能干细胞(iPSC)胚状体的IKr阻滞剂
- 大鼠心室肌细胞中的IKr阻滞剂
生化/生理作用
E-4031可选择性封闭hERG K+通道。
E-4031是一种抗心律不齐药物,属于III类。它是一种甲磺酰苯胺化合物,可有效治疗心律不齐并调节心室纤颤。E-4031介导转基因长QT 1型(LQT1)兔的动作电位持续时间(action potential duration ,APD)延长。人类 ether-a-go-go相关基因(hERG)中的异亮氨酸突变消除了其与E-4031的相互作用。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Molecular biology of K+ channels and their role in cardiac arrhythmias
The American Journal of Medicine, 110(1), 50-59 (2001)
Pronounced effects of HERG-blockers E-4031 and erythromycin on APD, spatial APD dispersion and triangulation in transgenic long-QT type 1 rabbits
PLoS ONE, 9(9), e107210-e107210 (2014)
Journal of cardiology, 71(4), 401-408 (2017-11-18)
Missense mutations in KCNH2, a gene encoding the Kv11.1 channel, cause long QT syndrome (LQTS) type 2 primarily by disrupting the intracellular transport of Kv11.1 to the plasma membrane. The present study aimed to clarify the functional changes by two
Identification of small-molecule ion channel modulators in C. elegans channelopathy models
Nature Communications, 9(1), 3941-3941 (2018)
Scientific reports, 8(1), 16218-16218 (2018-11-06)
Optically pumped magnetometers are becoming a promising alternative to cryogenically-cooled superconducting magnetometers for detecting and imaging biomagnetic fields. Magnetic field detection is a completely non-invasive method, which allows one to study the function of excitable human organs with a sensor
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