应用
β在血液CNS肿瘤的鉴别诊断中,使用来自人体尿液的2-微球蛋白检测体液CSF参数。通过全基因组计算扫描和合理设计肽疫苗,它还被用于识别丙型肝炎病毒的CTL表位。
生化/生理作用
β2微球蛋白(β2-M)是与细胞表面上I类主要组织相容性复合体(MHC)抗原的重链相关的多肽。这种相互作用是动态的,在MHC抗原的稳定性及其在CD8+ 细胞中呈递肽抗原的能力中起关键作用。MHC重链和β2-M的瞬时复合体可通过与许多分子伴侣相互作用而组装到TAP分子(与抗原加工相关的转运蛋白)中。加工肽结合可将I类β2-M复合体释放到细胞表面。不结合会导致蛋白酶体降解。
包装
包装规格基于蛋白含量。
制备说明
按照Berggard和Bearn的方法制备。
免责声明
仅供研究使用。本品在法国的科研应用受到监管,包括用于进口和出口活动(法国《公共卫生法典》Public Health Code Article L 1211-1 paragraph 2)。如《公共卫生法典》所述,购买者(即最终用户)需要从法国研究部(France Ministry of Research)获得进口授权。订购此产品即代表您已确认获得合法的进口授权。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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