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安全信息

M4890

Sigma-Aldrich

β2-微球蛋白 来源于人类尿液

≥98% (SDS-PAGE), lyophilized powder

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About This Item

MDL编号:
UNSPSC代码:
12352202
NACRES:
NA.61

生物来源

human urine

质量水平

检测方案

≥98% (SDS-PAGE)

形式

lyophilized powder

分子量

11.6 kDa

UniProt登记号

储存温度

−20°C

基因信息

human ... B2M(567)

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应用

β在血液CNS肿瘤的鉴别诊断中,使用来自人体尿液的2-微球蛋白检测体液CSF参数。通过全基因组计算扫描和合理设计肽疫苗,它还被用于识别丙型肝炎病毒的CTL表位。

生化/生理作用

β2微球蛋白(β2-M)是与细胞表面上I类主要组织相容性复合体(MHC)抗原的重链相关的多肽。这种相互作用是动态的,在MHC抗原的稳定性及其在CD8+ 细胞中呈递肽抗原的能力中起关键作用。MHC重链和β2-M的瞬时复合体可通过与许多分子伴侣相互作用而组装到TAP分子(与抗原加工相关的转运蛋白)中。加工肽结合可将I类β2-M复合体释放到细胞表面。不结合会导致蛋白酶体降解。

包装

包装规格基于蛋白含量。

制备说明

按照Berggard和Bearn的方法制备。

免责声明

仅供研究使用。本品在法国的科研应用受到监管,包括用于进口和出口活动(法国《公共卫生法典》Public Health Code Article L 1211-1 paragraph 2)。如《公共卫生法典》所述,购买者(即最终用户)需要从法国研究部(France Ministry of Research)获得进口授权。订购此产品即代表您已确认获得合法的进口授权。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

法规信息

常规特殊物品

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