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Merck
CN

M4765

N-甲氧基琥珀酰-Ala-Ala-Pro-Val 对硝基苯胺

elastase substrate, chromogenic, ≥98% (HPLC), powder

别名:

N-（甲氧基琥珀酰基）-L-丙氨酰-L-丙氨酰-L-脯氨酰-L-缬氨酸4-硝基苯胺, N-（甲氧基琥珀酰基）-Ala-Ala-Pro-Val 4-硝基苯胺

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关于此项目

经验公式（希尔记法）:
C27H38N6O9
化学文摘社编号:
70967-90-7
分子量:
590.63
NACRES:
NA.32
PubChem Substance ID:
24896943
UNSPSC Code:
12352204
MDL number:
MFCD00077137
Beilstein/REAXYS Number:
6266359

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产品名称

N-甲氧基琥珀酰-Ala-Ala-Pro-Val 对硝基苯胺, elastase substrate

InChI

1S/C27H38N6O9/c1-15(2)23(26(38)30-18-8-10-19(11-9-18)33(40)41)31-25(37)20-7-6-14-32(20)27(39)17(4)29-24(36)16(3)28-21(34)12-13-22(35)42-5/h8-11,15-17,20,23H,6-7,12-14H2,1-5H3,(H,28,34)(H,29,36)(H,30,38)(H,31,37)/t16-,17-,20-,23-/m0/s1

SMILES string

[H][C@]1(CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CCC(=O)OC)C(=O)N[C@@H](C(C)C)C(=O)Nc2ccc(cc2)[N+]([O-])=O

InChI key

VLVGCNNWNUERRZ-OSAZLGQLSA-N

assay

≥98% (HPLC)

form

powder

solubility

DMF: soluble 25 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

Quality Level

300

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Application

MeO-SucAAPVpNA已用于测量嗜中性粒细胞弹性蛋白酶活性：
  • 人和小鼠嗜中性粒细胞体外补充锌补充造成的结果
  • 确定老化嗜中性粒细胞的功能特性，以评估它们在促进肿瘤转移方面的作用
  • 确定伯尔硬胡桃（Sclerocarya birrea (A. Rich.)）的抗弹性蛋白酶作用Hochst

Biochem/physiol Actions

人类白细胞弹性蛋白酶 (HLE) 是一种丝氨酸蛋白酶，与炎症和组织退化相关。它是最具破坏性的蛋白酶之一，其在肺气肿进程中的作用得到了广泛研究。这种肽酶可被HLE及不同物种和细胞的其他弹性蛋白酶选择性水解。弹性蛋白酶样蛋白酶切割MeO-SucAPVVpNA对于肿瘤坏死因子-α (TNF-α)和白细胞介素-1α (IL-1α)诱导的血小板活化因子(PAF)合成至关重要。由于释放4-硝基苯胺，底物的酶促水解速率随着吸光度增加。通常在400 nm或更高波长处测量吸光度。

General description

人白细胞弹性蛋白酶的底物。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000511431
0000511431
0000502268
0000502268
0000455359

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Rami A Al-Horani et al.
ACS omega, 6(19), 12699-12710 (2021-06-01)
Human neutrophil elastase (HNE) is a serine protease that plays vital roles in inflammation, innate immune response, and tissue remodeling processes. HNE has been actively pursued as a drug target, particularly for the treatment of cardiopulmonary diseases. Although thousands of
Y M van der Geld et al.
Clinical and experimental immunology, 129(3), 562-570 (2002-08-29)
Anti-neutrophil cytoplasmic antibodies (ANCA) against proteinase 3 (PR3) are strongly associated with Wegener's granulomatosis (WG) and are thought to be involved in its pathogenesis. Levels of PR3-ANCA do not always correspond to clinical disease activity. To investigate the relationship between
Hanife Ataoglu et al.
Clinical oral implants research, 13(5), 470-476 (2002-11-28)
The aim of this study was to determine interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) levels and neutrophil elastase (NE) activity in peri-implant crevicular fluid (PICF) of smoker and nonsmoker patients, and to investigate their relationships with clinical parameters. A total
S C Wright et al.
Cancer research, 58(23), 5570-5576 (1998-12-16)
Studies on the mechanism of apoptosis in this laboratory support a model in which signal transduction involving caspase 3 leads to activation of a serine protease called Mr 24,000 apoptotic protease (AP24), which then induces internucleosomal DNA fragmentation in the
N P Rodis et al.
Journal of enzyme inhibition, 16(2), 95-105 (2001-05-09)
A series of novel low molecular weight thiocarbamate esters (1e-6e) were synthesized and evaluated as inhibitors of human leukocyte elastase (HLE). The thiocarbamate esters studied consist of a substituted primary or secondary aliphatic or aromatic amine and a 1-phenyl-1H-tetrazole-5-thiol (Table
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Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

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