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Merck
CN
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主要文件

安全信息

M4603

Sigma-Aldrich

乙酰基-[Nle4，Asp5，D-2-Nal7，Lys10]-环-α-黑素细胞刺激素酰胺片段4-10

≥95% (HPLC)

别名:

SHU9119

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About This Item

经验公式（希尔记法）:
C54H71N15O9
分子量:
1074.24
MDL编号:
MFCD02093607
UNSPSC代码:
51111800
NACRES:
NA.32

质量水平

200

方案

≥95% (HPLC)

UniProt登记号

P01189

储存温度

−20°C

基因信息

human ... POMC(5443)

Amino Acid Sequence

Ac-Nle-cyclo(Asp-His-Nal-Arg-Trp-Lys-NH2)

生化/生理作用

筛选环状内酰胺黑皮质素激动剂MTII的类似物导致了拟南芥SHU9119的鉴定。该化合物与刺鼠肽具有相同的药理特性，因为它是黑皮质素-4受体的有效拮抗剂和黑皮质素-3受体的较弱拮抗剂。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCL6653
BCBS0887V
BCBH6799V
1403981
063K1005

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V J Hruby et al.
Journal of medicinal chemistry, 38(18), 3454-3461 (1995-09-01)
The cloning of the melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH) receptors (MC1-R and MC2-R, respectively) recently has led to the identification of three additional melanocortin receptors, MC3-R, MC4-R, and MC5-R. The MC2 receptor primarily recognizes only ACTH peptides, but
W Fan et al.
Nature, 385(6612), 165-168 (1997-01-09)
Dominant alleles at the agouti locus (A) cause an obesity syndrome in the mouse, as a consequence of ectopic expression of the agouti peptide. This peptide, normally only found in the skin, is a high-affinity antagonist of the melanocyte-stimulating hormone
Anna Fosch et al.
International journal of molecular sciences, 24(2) (2023-01-22)
Sensing of long-chain fatty acids (LCFA) in the hypothalamus modulates energy balance, and its disruption leads to obesity. To date, the effects of saturated or unsaturated LCFA on hypothalamic-brown adipose tissue (BAT) axis and the underlying mechanisms have remained largely

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