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生物来源
Mycobacterium tuberculosis (bovine strain)
描述
mixture of homologous acids
形式
powder
官能团
carboxylic acid
脂质类型
unsaturated FAs
储存温度
−20°C
生化/生理作用
霉菌酸是在霉菌分类群细菌的细胞壁中发现的含有分子的长链脂肪酸。结核分枝杆菌（牛株）的霉菌酸可用于研究对抗生素药物治疗的耐药性和结核菌毒性的机制。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
Anna E Grzegorzewicz et al.
Nature chemical biology, 8(4), 334-341 (2012-02-22)
New chemotherapeutics active against multidrug-resistant Mycobacterium tuberculosis are urgently needed. We report on the identification of an adamantyl urea compound that shows potent bactericidal activity against M. tuberculosis and a unique mode of action, namely the abolition of the translocation
Damien J Montamat-Sicotte et al.
The Journal of clinical investigation, 121(6), 2493-2503 (2011-05-18)
Current tuberculosis (TB) vaccine strategies are largely aimed at activating conventional T cell responses to mycobacterial protein antigens. However, the lipid-rich cell wall of Mycobacterium tuberculosis (M. tuberculosis) is essential for pathogenicity and provides targets for unconventional T cell recognition.
Guanghou Shui et al.
EMBO molecular medicine, 4(1), 27-37 (2011-12-08)
Mycolic acids are attractive diagnostic markers for tuberculosis (TB) infection because they are bacteria-derived, contain information about bacterial species, modulate host-pathogen interactions and are chemically inert. Here, we present a novel approach based on mass spectrometry. Quantification of specific precursor
Mervyn Beukes et al.
Chemistry and physics of lipids, 163(8), 800-808 (2010-09-30)
Cell wall mycolic acids (MA) from Mycobacterium tuberculosis (M.tb) are CD1b presented antigens that can be used to detect antibodies as surrogate markers of active TB, even in HIV coinfected patients. The use of the complex mixtures of natural MA
Asselineau, J.
The Bacterial Lipids, - (1962)
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