M4531
甲氯芬那酸 钠盐
别名:
2-[(2,6-二氯-3-甲基苯基)氨基]苯甲酸 钠盐
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关于此项目
线性分子式:
C14H10Cl2NO2Na
化学文摘社编号:
分子量:
318.13
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
228-983-3
MDL number:
InChI key
CHGIZYUDGOIAFY-UHFFFAOYSA-N
InChI
1S/C14H11Cl2NO2.Na.H/c1-8-6-7-10(15)13(12(8)16)17-11-5-3-2-4-9(11)14(18)19;;/h2-7,17H,1H3,(H,18,19);;
SMILES string
[Na].Cc1ccc(Cl)c(Nc2ccccc2C(O)=O)c1Cl
biological source
synthetic (organic)
assay
≥93% (HPLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless to faintly brownish-yellow, water: 50 mg/mL, clear, colorless to faintly yellow, water: 50 mg/mL, clear, colorless to very faintly brown
Quality Level
General description
甲氯芬那酸由两个垂直扭曲的芳基部分组成，它包括N-2,6-二氯-3-甲基苯基和N-2-苯甲酸基团。由于该化合物的水溶性低，因此能够以钠盐的形式出售。
Application
甲氯芬那酸钠盐已被用于：
- 抑制热诱导的白蛋白变性
- 作为药物制剂，制备用于电生理学研究的灌注液
- 阻止间隙连接
Biochem/physiol Actions
环加氧酶（IC50 = 0.6 μM）和5-脂氧合酶（IC50 = 46.3 μM）抑制剂。
甲氯芬那酸（MFA）是一种非甾体类抗炎药、镇痛药和解热药。它能够抑制前列腺素的生物合成途径，并且被用于治疗术后以及创伤性炎症和肿胀。MFA在打开电压门控性钾通道Q亚家族成员2/成员3（KCNQ2/Q3）方面发挥作用。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Boctor, A.M., et al.
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Jungryul Ahn et al.
Frontiers in cellular neuroscience, 16, 889663-889663 (2022-05-24)
Retinal prostheses have shown some clinical success in patients with retinitis pigmentosa and age-related macular degeneration. However, even after the implantation of a retinal prosthesis, the patient's visual acuity is at best less than 20/420. Reduced visual acuity may be
High solubility piperazine salts of the nonsteroidal anti-inflammatory drug (NSAID) meclofenamic acid
Sanphui P, et al.
Crystal Growth & Design, 12(4), 2023-2036 (2012)
Homeostatic plasticity shapes cell-type-specific wiring in the retina
Tien NW, et al.
Neuron, 94(3), 656-665 (2017)
Ken-ichiro Hayashida et al.
Brain research, 1317, 80-86 (2010-01-12)
Descending noradrenergic inhibition is an important endogenous pain-relief mechanism which can be activated by local glutamate signaling. In the present study, we examined the effect of glutamate transporter activation by riluzole in the regulation of activity of locus coeruleus (LC)
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