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Merck
CN
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安全信息

M4069

Sigma-Aldrich

微囊藻素 YR 来源于铜绿微囊藻菌

cyanotoxin

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About This Item

经验公式（希尔记法）:
C52H72N10O13
CAS号:
101064-48-6
分子量:
1045.19
MDL编号:
MFCD00236437
UNSPSC代码:
12352202
PubChem化学物质编号:
24896901

生物来源

microbial (Microcystis aerguinosa)

质量水平

200

方案

≥90% (HPLC)

表单

powder

分子量

~1.0 kDa

颜色

white

溶解性

methanol: 2 mg/mL ((further dilute to 10% (v/v) methanol))
DMSO: soluble
ethanol: soluble

储存温度

−20°C

SMILES字符串

CO[C@@H](Cc1ccccc1)[C@@H](C)\C=C(C)\C=C\[C@@H]2NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](C)[C@@H](NC(=O)[C@H](Cc3ccc(O)cc3)NC(=O)[C@@H](C)NC(=O)C(=C)N(C)C(=O)CC[C@@H](NC(=O)[C@H]2C)C(O)=O)C(O)=O

InChI

1S/C52H72N10O13/c1-28(25-29(2)41(75-8)27-34-13-10-9-11-14-34)16-21-37-30(3)44(65)59-39(50(71)72)22-23-42(64)62(7)33(6)47(68)56-32(5)46(67)60-40(26-35-17-19-36(63)20-18-35)49(70)61-43(51(73)74)31(4)45(66)58-38(48(69)57-37)15-12-24-55-52(53)54/h9-11,13-14,16-21,25,29-32,37-41,43,63H,6,12,15,22-24,26-27H2,1-5,7-8H3,(H,56,68)(H,57,69)(H,58,66)(H,59,65)(H,60,67)(H,61,70)(H,71,72)(H,73,74)(H4,53,54,55)/b21-16+,28-25+/t29-,30-,31+,32+,37-,38-,39+,40-,41-,43+/m0/s1

InChI key

OWHASZQTEFAUJC-HVUCWAFBSA-N

一般描述

Microcystin is a potent cyanotoxin produced by the bloom of Microcystis aeruginosa. It is harmful to aquatic animals. It is a heptapeptide and exists as multiple variant forms. pCO2 and nitrogen levels modulate the toxic variants levels. It elicits damage to the liver and other organs.

应用

Microcystin YR from Microcystis aeruginosa has been used to assess cytotoxicity in neutrophils using DNA fragmentation and cell viability assays and as a reference standard in the quantification of microcystin from water samples.

生化/生理作用

Microcystin YR inhibits protein phosphatase type 2A and protein phosphatase type 1.
Microcystin YR inhibits protein phosphatase type 2A and protein phosphatase type 1. Toxicity to undifferentiated cells was seen by inhibition of neutral red uptake, >80% at 100 μM, after 48 h.

象形图

Skull and crossbones
GHS06

警示用语：

Danger

危险分类

Acute Tox. 1 Inhalation - Acute Tox. 2 Dermal - Acute Tox. 2 Oral - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

储存分类代码

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

新产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLBS2570V
SLBR1121V
SLBK9229V
SLBH8446V
SLBG7589V

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Elevated pCO2 causes a shift towards more toxic microcystin variants in nitrogen-limited Microcystis aeruginosa
Liu J, et al.
FEMS Microbiology Ecology, 92(2) (2016)
Analysis of chemokines and reactive oxygen species formation by rat and human neutrophils induced by microcystin-LA,-YR and-LR
Kujbida P, et al.
Toxicon, 51(7), 1274-1280 (2008)
Accumulation of microcystin (LR, RR and YR) in three freshwater bivalves in Microcystis aeruginosa bloom using dual isotope tracer
Kim MS, et al.
Marine drugs, 15(7), 226-226 (2017)
Isabel M Moreno et al.
Journal of agricultural and food chemistry, 52(19), 5933-5938 (2004-09-16)
The presence of cyanobacterial toxins (microcystins) in waters and food increases the risk of toxicity to animal and human health. These toxins can degrade in the human gastrointestinal tract before they are absorbed. To evaluate this possible degradation, water samples
Andy Ng et al.
Environmental science & technology, 46(19), 10697-10703 (2012-09-11)
The efficiency of current microcystin detection methods has been hampered by the low detection limits required in drinking water and that routine detection is restricted to a few of the congeners with high degree of undesired cross-reactivity. Here, we report
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