生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
表单
buffered aqueous solution
分子量
antigen ~40 kDa
种属反应性
human
包装
antibody small pack of 25 μL
浓度
~1.4 mg/mL
技术
western blot: 1-2 μg/mL using lysates of HEK-293T cells transfected with human Mnk1
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MKNK1(8569)
一般描述
MNK1 is a serine-threonine kinase that is activated by ERK or p38 MAPK signaling cascades and modulates translation through eIF4E phosphorylation. Human MNK1 has two C-terminal splice variants, namely, MNK1a and MNK1b. While MNK1a is expressed in the cytoplasm, MNK1b is mainly localized at the nucleus . Anti-MNK1 antibody is specific for human Mnk1 (40 kDa). In immunoblotting, staining of the Mnk1 band is specifically inhibited by the immunizing peptide.
免疫原
synthetic peptide corresponding to amino acids 12-27 of human MNK1, conjugated to KLH.
应用
Anti-MNK1 antibody is suitable for use in western blot (1-2 μg/mL using lysates of HEK-293T cells transfected with human Mnk1).
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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储存分类代码
10 - Combustible liquids
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
Takeshi Ueda et al.
Molecular and cellular biology, 24(15), 6539-6549 (2004-07-16)
Mnk1 and Mnk2 are protein kinases that are directly phosphorylated and activated by extracellular signal-regulated kinase (ERK) or p38 mitogen-activated protein (MAP) kinases and implicated in the regulation of protein synthesis through their phosphorylation of eukaryotic translation initiation factor 4E
Ana O'Loghlen et al.
Experimental cell research, 299(2), 343-355 (2004-09-08)
In this paper, we report the identification and molecular characterization of a splice variant of human Mnk1 which has been named as Mnk1b. Human Mnk1b mRNA is homologous to human Mnk1 mRNA but lacking a region corresponding to exon 19
Maria Buxade et al.
Frontiers in bioscience : a journal and virtual library, 13, 5359-5373 (2008-05-30)
The human MAP kinase-interacting kinases (or MAP kinase signal-integrating kinases), Mnks, comprise a group of four proteins derived from two genes (Gene symbols: MKNK1 and MKNK2) by alternative splicing. Mnk1a/b differ at their C-termini, as do Mnk2a/2b: in each case
R Fukunaga et al.
The EMBO journal, 16(8), 1921-1933 (1997-04-15)
We have developed a novel expression screening method for identifying protein kinase substrates. In this method, a lambda phage cDNA expression library is screened by in situ, solid-phase phosphorylation using purified protein kinase and [gamma-32P]ATP. Screening a HeLa cDNA library
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