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一般描述
IgM抗体以五聚体的形式存在于血清中，其是通过对抗原的反应而产生的来源于鼠骨髓瘤的IgM, κ是由BAPC/c小鼠皮下注入的TEPC 183肿瘤细胞系产生的。
IgM是一种脊椎动物中高度保守的抗体，在免疫应答过程中早期表达。它是由腹膜B细胞分泌的。
Determined by the absorbance at 280 nm (E1%/280 = 11.8). Each vial contains at least 1 mg of purified myeloma protein.
特异性
TEPC 183肿瘤细胞系来源于原始诱导的浆细胞瘤，并在BALB/c小鼠皮下携带。TEPC 183细胞系的半抗原结合特异性尚未确定。它可特异性识别小鼠IgM。免疫球蛋白的识别性和纯度可通过免疫电泳进行确定。
应用
来自小鼠骨髓瘤的IgM, Kappa已被用于：
- 夹心法酶联免疫吸附试验 (ELISA)
- 流式细胞术
- 斑点免疫结合试验
生化/生理作用
IgM在凋亡细胞的吞噬中起关键作用。血清IgM水平降低会导致自身免疫反应增强，并增加感染风险。IgM显示出多反应和自动反应功能。它可通过介导基于组织的分子的清除在组织动态平衡中起关键作用。IgM具有与N-连接的糖基化位点，其中糖是甘露糖、半乳糖、N-乙酰氨基葡萄糖和唾液酸。IgM连接的琼脂糖树脂经检测是有效的结合物结合。
外形
溶于含有0.05 M Tris(pH 8.0)、0.5 M氯化钠、0.02%叠氮化钠的溶液中
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储存分类代码
12 - Non Combustible Liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Matthew P Collin et al.
Transplantation, 79(6), 722-725 (2005-03-24)
Graft-versus-host disease (GvHD), a life-threatening complication of bone marrow transplantation, is initiated by donor T cells reacting to recipient dendritic cells (DC). GvHD can be controlled by attenuating donor T cells, but few strategies exist to target DC, particularly resident
A fast and simple dot-immunobinding assay for quantification of mouse immunoglobulins in hybridoma culture supernatants
Sulimenko T and Draber P
Journal of Immunological Methods, 289(1-2), 89-95 (2004)
A-O Hovden et al.
Scandinavian journal of immunology, 62(1), 36-44 (2005-08-12)
The aim of this study was to compare the kinetics and the magnitude of the humoral immune response to two different influenza vaccine formulations, whole and split virus vaccines. BALB/c mice were immunized intramuscularly with one or two doses (3
A monoclonal antibody that specifically binds chitosan in vitro and in situ on fungal cell walls
Schubert M, et al.
Journal of microbiology and biotechnology, 20(8), 1179-1184 (2010)
Max Schubert et al.
Journal of microbiology and biotechnology, 20(8), 1179-1184 (2010-08-28)
We report the generation of the first monoclonal antibody that specifically binds to the polysaccharide chitosan. Mice were immunized with a mixture of chitosans, and hybridoma clones were screened for specific binders resulting in the isolation of a single clone
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