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Merck
CN
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文件

安全信息

M3781

Sigma-Aldrich

6α-Methylprednisolone 21-hemisuccinate sodium salt

lyophilized powder

别名:

6α-Methylprednisolone sodium succinate, MPSL, 6α-Methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione 21-hemisuccinate

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About This Item

线性分子式:
C26H33O8Na
CAS号:
2375-03-3
分子量:
496.53
EC 号:
219-156-8
MDL编号:
MFCD00152612
UNSPSC代码:
51111800
PubChem化学物质编号:
24896873
NACRES:
NA.77

生物来源

synthetic

质量水平

100

无菌性

non-sterile

检测方案

≥98.00% (TLC)

形式

lyophilized powder

技术

toxicology assay: suitable

溶解性

water: 50 mg/mL, clear, colorless to faintly yellow

运输

ambient

储存温度

room temp

SMILES字符串

[Na+].C[C@H]1CC2C3CC[C@](O)(C(=O)COC(=O)CCC([O-])=O)[C@@]3(C)C[C@H](O)C2[C@@]4(C)C=CC(=O)C=C14

InChI

1S/C26H34O8.Na/c1-14-10-16-17-7-9-26(33,20(29)13-34-22(32)5-4-21(30)31)25(17,3)12-19(28)23(16)24(2)8-6-15(27)11-18(14)24;/h6,8,11,14,16-17,19,23,28,33H,4-5,7,9-10,12-13H2,1-3H3,(H,30,31);/q;+1/p-1/t14-,16-,17-,19-,23+,24-,25-,26-;/m0./s1

InChI key

FQISKWAFAHGMGT-SGJOWKDISA-M

基因信息

human ... NR3C1(2908)

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相关类别

应用

6α-methylprednisolone 21-hemisuccinate sodium salt has been used to investigate glucocorticoid-induced osteonecrosis under hypoxic conditions in the MC3T3-E1 osteoblast cell line using a cell cytotoxicity assay, flow cytometry and western blotting.

生化/生理作用

Glucocorticoid with slightly longer half-life than that of prednisolone.

外形

Lyophilized containing ~5% phosphate buffer salts.

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H351,H360

预防措施声明

P201 - P308 + P313

危险分类

Carc. 2 - Repr. 1B

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

法规信息

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[The issue of methylprednisolone sodium succinate dosage for use].
Yu-cai Zhang et al.
Zhonghua er ke za zhi = Chinese journal of pediatrics, 49(5), 389-390 (2011-06-01)
Julie M Jones et al.
The Journal of the American Osteopathic Association, 112(2), 90-92 (2012-02-15)
Hypocomplementemic urticarial vasculitis syndrome (HUVS) is a type III hypersensitivity reaction characterized by urticaria with persistent acquired hypocomplementemia. Although HUVS is uncommon, it is important for physicians to be familiar with this disease, as the initial presentation is often life-threatening
Dapsone hypersensitivity syndrome complicated by Scedosporium apiospermum pneumonia in an immunocompetent patient.
L Ceccarelli et al.
Infection, 40(4), 459-462 (2011-11-30)
Rina Ulmansky et al.
Journal of controlled release : official journal of the Controlled Release Society, 160(2), 299-305 (2012-01-10)
We have previously shown that intravenous (i.v.) treatment with sterically stabilized nano-liposomes (NSSL) actively remote-loaded with the glucocorticoid (GC) methylprednisolone hemisuccinate (NSSL-MPS) or betamethasone hemisuccinate (NSSL-BMS) significantly decreased severity of adjuvant arthritis in Lewis rats (a model of human rheumatoid
Takaaki Kitakawa et al.
Documenta ophthalmologica. Advances in ophthalmology, 124(3), 249-254 (2012-03-10)
The purpose of this study was to report a patient with acute zonal occult outer retinopathy (AZOOR) unilaterally, who received steroid pulse therapy. A 42-year-old woman presented with photopsias and severe vision loss in her left eye. Visual acuity was
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