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Merck
CN
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文件

M3445

Sigma-Aldrich

厚朴酚

≥90% (HPLC), from plant

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别名:
2,2'-双香豆素, 5,5′-Diallyl-2,2′-biphenyldiol
经验公式（希尔记法）:
C18H18O2
CAS号:
528-43-8
分子量:
266.33
MDL编号:
MFCD00016658
UNSPSC代码:
12352100
PubChem化学物质编号:
24896843
NACRES:
NA.25

生物来源

plant

质量水平

200

检测方案

≥90% (HPLC)

溶解性

ethanol: soluble 1 mg/mL
methanol: soluble 1.5 mg/mL

抗生素抗菌谱

Gram-negative bacteria
Gram-positive bacteria
fungi

应用

metabolomics
vitamins, nutraceuticals, and natural products

作用机制

cell membrane | interferes

储存温度

2-8°C

SMILES字符串

Oc1ccc(CC=C)cc1-c2cc(CC=C)ccc2O

InChI

1S/C18H18O2/c1-3-5-13-7-9-17(19)15(11-13)16-12-14(6-4-2)8-10-18(16)20/h3-4,7-12,19-20H,1-2,5-6H2

InChI key

VVOAZFWZEDHOOU-UHFFFAOYSA-N

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相关类别

一般描述

厚朴酚是从不同中草药厚朴的根和茎皮中提取的一种具有生物活性的新木质素。它具有羟基化的双酚结构，类似于其结构异构体厚朴酚。它是一种亲脂化合物。

应用

厚朴酚已被用于：
  • 检测其对肌少症小鼠肌肉萎缩及巨噬细胞亚型的影响
  • 在血管生成实验中检测其对人脐静脉内皮细胞(HUVEC)的抑制作用
  • 检测其对念珠菌生长、超微结构和生物膜形成的抑制作用
  • 制备固定化氨基功能化介孔二氧化硅颗粒，以进行缓释研究

生化/生理作用

厚朴酚具有抗抑郁和神经退行性。它还被认为是一种有效的抗癌药物，参与减少细胞增殖，细胞毒性和诱导细胞凋亡。
厚朴酚是从木兰科植物 厚朴的根和茎皮中分离得到的一种具有生物活性的植物成分 ，具有抗真菌、 抗菌 和抗氧化作用。厚朴酚还通过干扰 NF-κ 而显示抗炎活性 B 信号传导。由于其能够抑制 IL-6 诱导的 STAT3 活化，因此其似乎也具有与血管疾病（如动脉粥样硬化）相关的抗炎属性。

警示用语：

Danger

危险分类

Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves

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Hanna Kuk et al.
Scientific reports, 7(1), 17820-17820 (2017-12-21)
Due to gravity the venous vasculature in the lower extremities is exposed to elevated pressure levels which may be amplified by obesity or pregnancy. As a consequence, venules dilate and may be slowly transformed into varicose or spider veins. In
Development of a prolonged-release drug delivery system with magnolol loaded in amino-functionalized mesoporous silica
Stefanache A, et al.,
Applied Sciences, 237-237 (2017)
Rajendra Karki et al.
Experimental cell research, 319(20), 3238-3250 (2013-08-03)
Increased proliferation and migration of vascular smooth muscle cells (VSMCs) contribute importantly to the formation of both atherosclerotic and restenotic lesions. The objective of this study was to investigate the effect of magnolol on VSMC migration. The proteolytic activity of
Yongtao Bai et al.
Steroids, 135, 73-78 (2018-03-21)
Evidence showed that the stress hormone corticosterone (CORT) injection resulted in dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis implicated in major depressive disorder. Magnolol, main constituent identified in the barks of Magnolia officinalis, exerted antidepressant effects in a rat model of
Jianhong Zhang et al.
BioMed research international, 2019, 1847130-1847130 (2019-06-27)
Over years, various biological constituents are isolated from Traditional Chinese Medicine and confirmed to show multifunctional activities. Magnolol, a hydroxylated biphenyl natural compound isolated from Magnolia officinalis, has been extensively documented and shows a range of biological activities. Many signaling
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