生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
affinity isolated antibody
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 120 kDa
种属反应性
rat
技术
immunoprecipitation (IP): 5-10 μg using a rat brain extract (S1 fraction).
microarray: suitable
western blot: 0.25-0.5 μg/mL using rat brain extract (S1 fraction)
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... APBA2(321)
mouse ... Apba2(11784)
rat ... Apba2(83610)
一般描述
Munc-18-1 interacting protein 2 (Mint2), also called X11L, shares 50% homology with Mint1 and both are expressed exclusively in brain and bind Munc-18-1 with high affinity. It has N-terminal Munc-18-1-interacting domain (MID), a middle phosphotyrosine-binding (PTB) domain, and two C-terminal PDZ domain. It belongs to mammalian LIN-10 protein family. Mint 2 is present in neurons.
免疫原
synthetic peptide corresponding to amino acids 1-18, located at the N-terminus of rat mint2, conjugated to KLH. This sequence is highly conserved (single amino acid substitution) in mouse mint2 and shows limited homology (66% identity) to human mint2. It does not share homology with the mint1 and mint3 isoforms.
应用
Anti-Mint2 antibody produced in rabbit has been used in:
- immunoblotting
- immunoprecipitation
- immunostaining
生化/生理作用
Munc-18-1 interacting protein 2 (Mint2) participates in vesicle exocytosis. Mint 2 interacts with amyloid-β precursor protein (APP) and presenilins. It favors phosphorylation of β-amyloid precursor protein family members APP and Amyloid-like protein 2 (APLP2) in response to cellular stress, by facilitating c-Jun N-terminal kinase mediated phosphorylation.
外形
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.
免责声明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
新产品
Mint proteins are required for synaptic activity-dependent amyloid precursor protein (APP) trafficking and amyloid $\beta$ generation
Sullivan S, et al.
The Journal of Biological Chemistry, 289(22), 15374-15383 (2014)
Facilitation of stress-induced phosphorylation of beta-amyloid precursor protein family members by X11-like/Mint2 protein
Taru H and Suzuki T
Test, 279(20), 21628-21636 (2004)
Intracellular amyloid precursor protein sorting and amyloid-$\beta$ secretion are regulated by Src-mediated phosphorylation of Mint2
Chaufty J, et al.
The Journal of Neuroscience, 32(28), 9613-9625 (2012)
Regulation of APP-dependent transcription complexes by Mint/X11s: differential functions of Mint isoforms
Biederer T, et al.
The Journal of Neuroscience, 22(17), 7340-7351 (2002)
Jeremy Chaufty et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(28), 9613-9625 (2012-07-13)
Mint adaptor proteins bind to the membrane-bound amyloid precursor protein (APP) and affect the production of pathogenic amyloid-β (Aβ) peptides related to Alzheimer's disease (AD). Previous studies have shown that loss of each of the three Mint proteins delays the
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