所有图片(1)
About This Item
经验公式（希尔记法）:
C22H43F3O6PLi
CAS号:
分子量:
498.48
MDL编号:
UNSPSC代码:
41106300
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥90% (NMR)
形式
powder
颜色
white to beige
溶解性
H2O: ≥5 mg/mL (warmed at 60 °C)
储存温度
2-8°C
SMILES字符串
CCCCCCCCCCCCCCCCOCC(COCC(F)(F)F)OP(OC)([O-])=O.[Li+]
InChI
1S/C22H44F3O6P.Li/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-29-18-21(31-32(26,27)28-2)19-30-20-22(23,24)25;/h21H,3-20H2,1-2H3,(H,26,27);/q;+1/p-1
InChI key
GDLMLQJISATCEL-UHFFFAOYSA-M
应用
MJ33锂盐已被用作过氧化物酶VI（Prdx6）抑制剂：
- 在体外和乳腺癌细胞系（MCF-7）细胞裂解物中研究其特异性Prdx6过氧化物酶活性
- 以研究其对与高氧暴露相关的急性肺损伤小鼠模型的影响
- 研究其作为治疗剂的潜在用途
生化/生理作用
MJ33作为激动剂诱导的烟酰胺腺嘌呤二核苷酸磷酸盐（NADPH）氧化酶2型（NOX2）活化的无毒和强效抑制剂。它还可以预防与小鼠肺炎症相关的肺损伤。MJ33是一种氟化脂质类似物，通过模拟底物的过渡态来阻断酶。
磷脂酶A2（PLA2）的新型，活性部位指导，特异性，竞争性和可逆性抑制剂。
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Fisher, A.B. et al.
American Journal of Physiology. Cell Physiology, 280, 748-748 (2001)
Bavneet Benipal et al.
Redox biology, 4, 321-327 (2015-02-01)
Lung injury associated with hyperoxia reflects in part the secondary effects of pulmonary inflammation and the associated production of reactive oxygen species due to activation of NADPH oxidase, type 2 (NOX2). Activation of NOX2 requires the phospholipase A2 (PLA2) activity
Inhibition of the phospholipase A2 activity of peroxiredoxin 6 prevents lung damage with exposure to hyperoxia
Benipal B, et al.
Redox Biology, 4, 321-327 (2015)
Cristian O'Flaherty et al.
Antioxidants (Basel, Switzerland), 9(1) (2020-01-08)
Peroxiredoxins (PRDXs) are antioxidant enzymes that protect cells from oxidative stress and play a role in reactive oxygen species (ROS)-mediated signaling. We reported that PRDXs are critical for human fertility by maintaining sperm viability and regulating ROS levels during capacitation.
Allelic variants of glutathione S-transferase P1-1 differentially mediate the peroxidase function of peroxiredoxin VI and alter membrane lipid peroxidation
Manevich Y, et al.
Free radical biology & medicine, 54, 62-70 (2013)
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