生物来源
human
质量水平
重组
expressed in E. coli
检测方案
≥95% (SDS-PAGE)
形式
lyophilized powder
分子量
16 kDa (including a 31 amino-acid spacer and 6-His tag)
包装
pkg of 0.1 mg
技术
cell culture | mammalian: suitable
UniProt登记号
储存温度
−20°C
基因信息
human ... MSTN(2660)
应用
Use recombinant myostatin to study its mechanisms of action in vitro.
生化/生理作用
Myostatin is a 25 KDa, homodimer, that acts on muscle to induce SMAD family transcription factors such as SMAD2 and SMAD3. It inhibits the differentiation of myoblasts into mature muscle fibers. Positive control for myostatin in Western blots and ELISA.
Positive control for myostatin in Western blots and ELISA.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
监管及禁止进口产品
H Takahashi et al.
Domestic animal endocrinology, 48, 62-68 (2014-06-08)
The purpose of this study was to determine whether myostatin alters glucose transporter-4 (GLUT4) expression in bovine skeletal muscles and myoblasts isolated from double-muscled (DM) and normal-muscled (NM) Japanese Shorthorn cattle. Plasma concentrations of glucose were lower in DM cattle
Karima Relizani et al.
Molecular therapy : the journal of the American Society of Gene Therapy, 22(8), 1423-1433 (2014-05-28)
Myostatin regulates skeletal muscle size via the activin receptor IIB (ActRIIB). However, its effect on muscle energy metabolism and energy-dependent muscle function remains largely unexplored. This question needs to be solved urgently since various therapies for neuromuscular diseases based on
R E Ferrell et al.
Genomics, 62(2), 203-207 (1999-12-28)
Myostatin is a recently identified member of the transforming growth factor-beta family of regulatory factors, also known as growth and differentiation factor 8 (GDF8). The nucleotide sequence of human myostatin was determined in 40 individuals. The invariant promoter contains a
Qiang Zhang et al.
The FEBS journal, 277(2), 466-476 (2009-12-18)
The ubiquitin ligase RING finger protein 13 gene (RNF13) was first identified in a screen for genes whose expression is regulated by myostatin in chicken fetal myoblasts. In this study, we demonstrate that the RNF13 gene is broadly expressed in
Yutaka Ohsawa et al.
PloS one, 10(7), e0133713-e0133713 (2015-08-01)
Myostatin, a muscle-specific transforming growth factor-β (TGF-β), negatively regulates skeletal muscle mass. The N-terminal prodomain of myostatin noncovalently binds to and suppresses the C-terminal mature domain (ligand) as an inactive circulating complex. However, which region of the myostatin prodomain is
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系技术服务部门