所有图片(4)
About This Item
经验公式（希尔记法）:
C18H20N2 · HCl
CAS号:
分子量:
300.83
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
溶解性
H2O: 3.4 mg/mL
ethanol: 5.6 mg/mL
创始人
Organon
储存温度
2-8°C
SMILES字符串
Cl.CN1CCN2C(C1)c3ccccc3Cc4ccccc24
InChI
1S/C18H20N2.ClH/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19;/h2-9,18H,10-13H2,1H3;1H
InChI key
YNPFMWCWRVTGKJ-UHFFFAOYSA-N
基因信息
human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , HRH1(3269) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358)
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应用
Mianserin hydrochloride has been used:
- as a reversible antagonist for serotonergic -protein coupled receptor (GPCR) - G-protein protein-coupled receptor (S7.1R)
- as an antidepressant in hippocampal astrocytes to test its effect on brain-derived neurotrophic factor (BDNF) mRNA expression
- as a 5-hydroxytryptamine (5-HT) receptor antagonist to study its effect on serotonin modulation
生化/生理作用
Antidepressant; antagonist/inverse agonist at 5-HT2 serotonin receptors; also blocks the H1 histamine receptor and the α2 adrenoceptor.
Mianserin is a tetracyclic compound with sedative property. It lacks anticholinergic activity and is not effective on serotoninergic mechanisms. Mianserin is eliminated post biotransformation as hydroxylation, N-oxidation and N-demethylation products.
特点和优势
This compound was developed by Organon. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
制备说明
Solutions may be stored for several days at 4°C.
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
D L Willins et al.
Neuroscience, 91(2), 599-606 (1999-06-12)
In this study, we demonstrate that clozapine and other atypical antipsychotic drugs induce a paradoxical internalization of 5-hydroxytryptamine-2A receptors in vitro and a redistribution of 5-hydroxytryptamine-2A receptors in vivo. We discovered that clozapine, olanzapine, risperidone and the putative atypical antipsychotic
P A Lavoie et al.
European journal of pharmacology, 369(3), 387-390 (1999-05-04)
In order to test potential links with other stereospecific neurobiological effects of mianserin, the present study explored the stereospecificity for inhibition of depolarization-induced Ca2+ uptake by mianserin. Synaptosomes from rat hippocampus were incubated with 45Ca2+ in either resting or depolarizing
Mianserin: a review of its pharmacological properties and therapeutic efficacy in depressive illness
Brogden RN, et al.
Drugs, 16(4), 273-301 (1978)
Anti-depressant fluoxetine reveals its therapeutic effect via astrocytes
Kinoshita M, et al.
EBioMedicine, 32(3), 72-83 (2018)
I M Leitch et al.
The Journal of pharmacy and pharmacology, 44(4), 315-320 (1992-04-01)
Some in-vitro pharmacological effects of a novel analogue of mianserin, 2-carboxamidino-1,2,3,4,10,14b-hexahydrodibenzo (c,f) pyrazino (1,2-alpha) azepine hydrochloride (FCC5) have been studied. FCC5 was a non-competitive antagonist of both histamine-induced contractions of the guinea-pig ileum and 5-HT-induced contractions of rat fundal strips
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