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M2449

Sigma-Aldrich

MB-3

≥95% (HPLC)

别名:

γ-丁内酯, 丁内酯3, (2R,3S)-rel-4-亚甲基-5-氧代-2-丙基四氢呋喃-3-羧酸

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About This Item

经验公式（希尔记法）:
C9H12O4
分子量:
184.19
MDL编号:
MFCD08702690
UNSPSC代码:
12352200
PubChem化学物质编号:
329817942
NACRES:
NA.77
产品M2449监管中，请联系销售询价或购买 联系客户支持

质量水平

100

方案

≥95% (HPLC)

表单

powder

颜色

white to off-white

溶解性

H2O: ≥10 mg/mL
DMSO: ≥20 mg/mL

储存温度

−20°C

SMILES字符串

CCC[C@H]1OC(=O)C(=C)[C@@H]1C(O)=O

InChI

1S/C9H12O4/c1-3-4-6-7(8(10)11)5(2)9(12)13-6/h6-7H,2-4H2,1H3,(H,10,11)/t6-,7+/m1/s1

InChI key

SRQUTZJZABSZRQ-RQJHMYQMSA-N

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酚红 钠盐 powder, BioReagent, suitable for cell culture, suitable for insect cell culture

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酚红 钠盐

酚红 钠盐 pH indicator dye

P4758

酚红 钠盐

酚红 钠盐 ACS reagent, Dye content 90 %

114537

酚红 钠盐

酚红 powder, BioReagent, suitable for cell culture

P3532

酚红

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

technique(s)

titration: suitable

technique(s)

titration: suitable

technique(s)

cell culture | mammalian: suitable

color

red to very dark red

color

red to brown

color

red to very dark red

color

dark red to dark brown

application(s)

diagnostic assay manufacturing

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

-

application(s)

diagnostic assay manufacturing

form

powder

form

powder

form

powder or crystals

form

powder

solubility

H2O: 1 mg/mL

solubility

water: 1 mg/mL, opaque, dark red

solubility

-

solubility

1 M NaOH: 1 mg/mL

应用

MB-3已被用作通用控制蛋白5 (GCN5)抑制剂：
  • 研究其对核纤层蛋白A/C相关pY19-Cav-2-介导组蛋白H3乙酰化的影响[1]
  • 分析其对拟南芥幼苗生长的影响[2]
  • 研究其对颅面软骨细胞成熟的影响[3]

生化/生理作用

MB-3 是一种 Gcn5 HAT（组蛋白乙酰转移酶）抑制剂；具有抗炎、抗癌作用。
MB-3可以修饰小鼠胚胎干细胞和酵母的基因表达。[4]它通过与GCN5中的乙酰辅酶CoA口袋结合来抑制通用控制蛋白5(GCN5)的乙酰转移酶活性。[3]

特点和优势

这种化合物是基因调控研究的特色产品。点击此处发现更多特色基因调控产品。在sigma.com/discover-bsm可了解更多关于生物活性小分子的其他研究领域。

储存分类代码

11 - Combustible Solids

WGK

nwg

闪点(°F)

Not applicable

闪点(°C)

Not applicable

  • 技术规格说明书

    • 历史批次信息供参考:

    分析证书(COA)

    Lot/Batch Number
    0000384127
    0000384127
    0000090057
    0000152959
    0000152959

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    在文件库中查找您最近购买产品的文档。

    访问文档库

    Felipe Aquea et al.
    Biochemical and biophysical research communications, 483(1), 664-668 (2016-12-21)
    Chemical inhibition of chromatin regulators provides an effective approach to investigate the roles of chromatin modifications in plant and animals. In this work, chemical inhibition of the Arabidopsis histone acetyltransferase activity by γ-butyrolactone (MB-3), the inhibitor of the catalytic activity
    Anissa Guillemin et al.
    PloS one, 14(11), e0225166-e0225166 (2019-11-22)
    To better understand the mechanisms behind cells decision-making to differentiate, we assessed the influence of stochastic gene expression (SGE) modulation on the erythroid differentiation process. It has been suggested that stochastic gene expression has a role in cell fate decision-making
    Hao Xu et al.
    Scientific reports, 10(1), 1817-1817 (2020-02-06)
    Mesenchymal stem cells (MSCs) specifically differentiate into cardiomyocytes as a potential way to reverse myocardial injury diseases, and uncovering this differentiation mechanism is immensely important. We have previously shown that histone acetylation/methylation and DNA methylation are involved in MSC differentiation
    Naomi Moris et al.
    Stem cells (Dayton, Ohio), 36(12), 1828-1838 (2018-10-03)
    Cell fate transitions in mammalian stem cell systems have often been associated with transcriptional heterogeneity; however, existing data have failed to establish a functional or mechanistic link between the two phenomena. Experiments in unicellular organisms support the notion that transcriptional
    M Semer et al.
    Nature chemical biology, 15(10), 992-1000 (2019-09-19)
    Post-translational modifications of histone variant H2A.Z accompany gene transactivation, but its modifying enzymes still remain elusive. Here, we reveal a hitherto unknown function of human KAT2A (GCN5) as a histone acetyltransferase (HAT) of H2A.Z at the promoters of a set
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