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M2389

N⁶-甲基-2′-脱氧腺苷

Name: N<SUP>6</SUP>-甲基-2′-脱氧腺苷
Brand: SIGMA

别名:

6mdA, N⁶-Me-dAdo, m⁶dA

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About This Item

经验公式（希尔记法）:

C₁₁H₁₅N₅O₃

CAS号:

2002-35-9

分子量:

265.27

MDL编号:

MFCD00055999

UNSPSC代码:

41106305

PubChem化学物质编号:

24896727

NACRES:

NA.51

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D5412

2′-脱氧尿苷

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1-甲基腺苷

方案

≥98% (TLC)

质量水平

200

表单

powder

溶解性

acetic acid: 49.00-51.00 mg/mL, clear, colorless

储存温度

−20°C

SMILES字符串

CNc1ncnc2n(cnc12)[C@H]3C[C@H](O)[C@@H](CO)O3

InChI

1S/C11H15N5O3/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(18)7(3-17)19-8/h4-8,17-18H,2-3H2,1H3,(H,12,13,14)/t6-,7+,8+/m0/s1

InChI key

DYSDOYRQWBDGQQ-XLPZGREQSA-N

应用

N⁶-甲基-2′-脱氧腺苷已用作标准品，结合超高效液相色谱法和三重四极杆质谱法（UHPLC-QQQ-MS/MS）来测定基因组DNA中的修饰碱基水平。它还用于研究其促进红系祖细胞增殖潜力。

生化/生理作用

N⁶-甲基-2′-脱氧腺苷（N6-Me-dAdo）是N⁶-甲基2′-脱氧腺苷3′,5′-二磷酸盐（N6MABP）的前体，后者是P2Y受体的一种竞争性和选择性抑制剂。它位于转录起始位点，在莱茵衣藻的增强基因表达中起作用。N⁶-Me-dAdo可增强内部转座因子，在果蝇的发育过程中处于较高水平。它在原核生物和原生生物中参与基因转录、DNA修复和复制的调节。与基因体互补的N⁶-Me-dAdo可能诱导人细胞的基因表达。

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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