M2319
甲氟喹 盐酸盐
≥98% (HPLC), Cx36 and Cx50 blocker, powder
别名:
(AS)-rel-a-(2R)-2-哌啶基-2,8-双(三氟甲基)-4-喹啉甲醇单盐酸盐
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关于此项目
经验公式（希尔记法）:
C17H17ClF6N2O
化学文摘社编号:
分子量:
414.77
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352202
EC Number:
257-412-0
MDL number:
产品名称
甲氟喹 盐酸盐, ≥98% (HPLC), powder
InChI
1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1
InChI key
WESWYMRNZNDGBX-YLCXCWDSSA-N
SMILES string
Cl[H].[H][C@@]1(CCCCN1)[C@@H](O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white
solubility
DMSO: soluble 38 mg/mL, H2O: insoluble
Quality Level
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相关类别
Application
使用盐酸甲氟喹：
- 基于不同剂量治疗耳蜗器官型培养物，以评估其在细胞凋亡相关细胞通路中的作用
- 筛选体外抗血吸虫活性
- 用于胶质母细胞瘤细胞的毒性分析
Biochem/physiol Actions
甲氟喹被广泛用作抗疟疾药物。它抑制疟原虫的80S核糖体。它有很多副作用，例如焦虑、头晕、颤抖、头痛和听觉损失。甲氟喹会通过细胞凋亡损伤耳蜗和前庭毛细胞。它还会损害螺旋神经节神经元、退化皮质神经元并且破坏神经元钙稳态。
间隙连接通道Cx36和Cx50的阻断剂。
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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