所有图片(1)
About This Item
经验公式(希尔记法):
C17H17ClF6N2O
CAS号:
分子量:
414.77
EC 号:
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white
溶解性
DMSO: soluble 38 mg/mL
H2O: insoluble
SMILES字符串
Cl[H].[H][C@@]1(CCCCN1)[C@@H](O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F
InChI
1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1
InChI key
WESWYMRNZNDGBX-YLCXCWDSSA-N
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应用
使用盐酸甲氟喹:
- 基于不同剂量治疗耳蜗器官型培养物,以评估其在细胞凋亡相关细胞通路中的作用
- 筛选体外抗血吸虫活性
- 用于胶质母细胞瘤细胞的毒性分析
生化/生理作用
甲氟喹被广泛用作抗疟疾药物。它抑制疟原虫的80S核糖体。它有很多副作用,例如焦虑、头晕、颤抖、头痛和听觉损失。甲氟喹会通过细胞凋亡损伤耳蜗和前庭毛细胞。它还会损害螺旋神经节神经元、退化皮质神经元并且破坏神经元钙稳态。
间隙连接通道Cx36和Cx50的阻断剂。
警示用语:
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Sophie Zaloumis et al.
Malaria journal, 11, 303-303 (2012-08-31)
Mechanistic within-host models relating blood anti-malarial drug concentrations with the parasite-time profile help in assessing dosing schedules and partner drugs for new anti-malarial treatments. A comprehensive simulation study to assess the utility of a stage-specific pharmacokinetic-pharmacodynamic (PK-PD) model for predicting
Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A
Rahim SAA, et al.
British Journal of Cancer, 117(6), 813-813 (2017)
Chanaki Amaratunga et al.
The Lancet. Infectious diseases, 12(11), 851-858 (2012-09-04)
Artemisinin-resistant Plasmodium falciparum has been reported in Pailin, western Cambodia, detected as a slow parasite clearance rate in vivo. Emergence of this phenotype in western Thailand and possibly elsewhere threatens to compromise the effectiveness of all artemisinin-based combination therapies. Parasite
Mahadeo A Sukhai et al.
The Journal of clinical investigation, 123(1), 315-328 (2012-12-04)
Despite efforts to understand and treat acute myeloid leukemia (AML), there remains a need for more comprehensive therapies to prevent AML-associated relapses. To identify new therapeutic strategies for AML, we screened a library of on- and off-patent drugs and identified
Identification of plumbagin and sanguinarine as effective chemotherapeutic agents for treatment of schistosomiasis
Zhang SM and Coultas KA
International Journal for Parasitology, Drugs and Drug Resistance, 3(11), 28-34 (2013)
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