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质量水平
方案
≥98% (HPLC)
表单
powder
储存条件
desiccated
颜色
white
溶解性
DMSO: soluble 38 mg/mL
H2O: insoluble
SMILES字符串
Cl[H].[H][C@@]1(CCCCN1)[C@@H](O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F
InChI
1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1
InChI key
WESWYMRNZNDGBX-YLCXCWDSSA-N
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应用
使用盐酸甲氟喹:
- 基于不同剂量治疗耳蜗器官型培养物,以评估其在细胞凋亡相关细胞通路中的作用
- 筛选体外抗血吸虫活性
- 用于胶质母细胞瘤细胞的毒性分析
生化/生理作用
甲氟喹被广泛用作抗疟疾药物。它抑制疟原虫的80S核糖体。它有很多副作用,例如焦虑、头晕、颤抖、头痛和听觉损失。甲氟喹会通过细胞凋亡损伤耳蜗和前庭毛细胞。它还会损害螺旋神经节神经元、退化皮质神经元并且破坏神经元钙稳态。
间隙连接通道Cx36和Cx50的阻断剂。
警示用语:
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
从最新的版本中选择一种:
分析证书(COA)
Malaria journal, 11, 303-303 (2012-08-31)
Mechanistic within-host models relating blood anti-malarial drug concentrations with the parasite-time profile help in assessing dosing schedules and partner drugs for new anti-malarial treatments. A comprehensive simulation study to assess the utility of a stage-specific pharmacokinetic-pharmacodynamic (PK-PD) model for predicting
Regulation of hypoxia-induced autophagy in glioblastoma involves ATG9A
British Journal of Cancer, 117(6), 813-813 (2017)
The Lancet. Infectious diseases, 12(11), 851-858 (2012-09-04)
Artemisinin-resistant Plasmodium falciparum has been reported in Pailin, western Cambodia, detected as a slow parasite clearance rate in vivo. Emergence of this phenotype in western Thailand and possibly elsewhere threatens to compromise the effectiveness of all artemisinin-based combination therapies. Parasite
Addition of exogenous NAD+ prevents mefloquine-induced neuroaxonal and hair cell degeneration through reduction of caspase-3-mediated apoptosis in cochlear organotypic cultures
Testing, 8(11), e79817-e79817 (2013)
Malaria journal, 12, 128-128 (2013-04-17)
This is the first case of Plasmodium knowlesi infection in a Japanese traveller returning from Malaysia. In September 2012, a previously healthy 35-year-old Japanese man presented to National Center for Global Health and Medicine in Tokyo with a two-day history
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