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Merck
CN

M2319

Sigma-Aldrich

甲氟喹 盐酸盐

≥98% (HPLC), powder

别名:

(AS)-rel-a-(2R)-2-哌啶基-2,8-双(三氟甲基)-4-喹啉甲醇单盐酸盐

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About This Item

经验公式(希尔记法):
C17H17ClF6N2O
CAS号:
分子量:
414.77
EC 号:
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77

质量水平

方案

≥98% (HPLC)

表单

powder

储存条件

desiccated

颜色

white

溶解性

DMSO: soluble 38 mg/mL
H2O: insoluble

SMILES字符串

Cl[H].[H][C@@]1(CCCCN1)[C@@H](O)c2cc(nc3c(cccc23)C(F)(F)F)C(F)(F)F

InChI

1S/C17H16F6N2O.ClH/c18-16(19,20)11-5-3-4-9-10(15(26)12-6-1-2-7-24-12)8-13(17(21,22)23)25-14(9)11;/h3-5,8,12,15,24,26H,1-2,6-7H2;1H/t12-,15+;/m1./s1

InChI key

WESWYMRNZNDGBX-YLCXCWDSSA-N

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应用

使用盐酸甲氟喹:
  • 基于不同剂量治疗耳蜗器官型培养物,以评估其在细胞凋亡相关细胞通路中的作用
  • 筛选体外抗血吸虫活性
  • 用于胶质母细胞瘤细胞的毒性分析

生化/生理作用

甲氟喹被广泛用作抗疟疾药物。它抑制疟原虫的80S核糖体。它有很多副作用,例如焦虑、头晕、颤抖、头痛和听觉损失。甲氟喹会通过细胞凋亡损伤耳蜗和前庭毛细胞。它还会损害螺旋神经节神经元、退化皮质神经元并且破坏神经元钙稳态。
间隙连接通道Cx36和Cx50的阻断剂。

象形图

Exclamation mark

警示用语:

Warning

危险声明

危险分类

Acute Tox. 4 Oral

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

dust mask type N95 (US), Eyeshields, Gloves


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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