M220
单克隆抗烟碱型乙酰胆碱受体（α7亚基） 小鼠抗
~5 mg/mL, clone mAb 306, purified immunoglobulin, buffered aqueous solution
别名:
Anti-CHRNA7-2, Anti-NACHRA7
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关于此项目
UNSPSC Code:
12352203
MDL number:
Conjugate:
unconjugated
Clone:
mAb 306, monoclonal
Application:
IHC (f)
Citations:
12
biological source
mouse
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
mAb 306, monoclonal
form
buffered aqueous solution
species reactivity
rat (denatured), human (denatured), chicken
concentration
~5 mg/mL
technique(s)
immunohistochemistry (frozen sections): 1:3,000
isotype
IgG1
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... CHRNA7(1139)
rat ... Chrna7(25302)
General description
烟碱型乙酰胆碱受体（nAChRs）作为配体门控通道，可调节内质网应激和神经递质的释放。这些受体还控制神经节和肌肉中的突触信号传导。nAChR的α7种形式在线粒体中表达，并调节Ca2+ 的运输和细胞色素c的释放。当在非兴奋性细胞中表达时，α7 nAChR介导细胞生长和存活
单克隆抗烟碱型乙酰胆碱受体（（α7）亚基）抗体对鸡的天然和变性α7个亚基以及大鼠和人类的变性α7个亚基具有特异性。该抗体不能与哺乳动物α7亚基的天然形式很好地结合。本品可用于鸡、大鼠和人体组织。
单克隆抗烟碱型乙酰胆碱受体（（α7）亚基）抗体对鸡的天然和变性α7个亚基以及大鼠和人类的变性α7个亚基具有特异性。该抗体不能与哺乳动物α7亚基的天然形式很好地结合。本品可用于鸡、大鼠和人体组织。
Immunogen
来自鸡的烟碱型乙酰胆碱受体的天然和变性α7亚基（氨基酸380-400，结合α-金环蛇毒素）和来自大鼠的变性α7 亚基。
Application
单克隆抗烟碱型乙酰胆碱受体（（α7）亚基）抗体适用于免疫细胞化学（使用多聚甲醛固定培养的大鼠嗜铬细胞以1：3000-1：50稀释）和免疫组化（使用冰冻切片以1：3,000稀释）。
成功使用该抗体的应用以及相关的同行评审论文如下所示。
蛋白质印迹（1篇论文）
蛋白质印迹（1篇论文）
Physical form
在20 mM Na3PO4，pH值7.2中的溶液，含150 mM NaCl和0.05%叠氮化钠。
Legal Information
经Salk Institute许可出售
Disclaimer
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
法规信息
常规特殊物品
低风险生物材料
此项目有
Rahul Srinivasan et al.
Molecular pharmacology, 81(6), 759-769 (2012-03-02)
We report the first observation that endoplasmic reticulum (ER) stress and the unfolded protein response (UPR) can decrease when a central nervous system drug acts as an intracellular pharmacological chaperone for its classic receptor. Transient expression of α4β2 nicotinic receptors
Mohamed R Elnagar et al.
PloS one, 12(12), e0189513-e0189513 (2017-12-21)
α7 nicotinic acetylcholine receptors (nAChRs) and N-methyl-D-aspartate receptors (NMDARs) are key mediators of central cholinergic and glutamatergic neurotransmission, respectively. In addition to numerous well-established functional interactions between α7 nAChRs and NMDARs, the two receptors have been proposed to form a
Galyna Gergalova et al.
PloS one, 7(2), e31361-e31361 (2012-02-24)
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that mediate synaptic transmission in the muscle and autonomic ganglia and regulate transmitter release in the brain. The nAChRs composed of α7 subunits are also expressed in non-excitable cells to regulate cell
Maxim Bychkov et al.
PloS one, 14(5), e0217339-e0217339 (2019-06-01)
Lynx1 is the first three-finger prototoxin found in the mammalian central nervous system. It is a GPI-anchored protein modulating nicotinic acetylcholine receptors (nAChRs) in the brain. Besides the brain, the Lynx1 protein was found in the lung and kidney. Endogenous
Junhua Xiao et al.
Molecular medicine reports, 22(3), 2235-2244 (2020-07-25)
Inflammatory bowel disease (IBD) is a chronic inflammatory condition with complex pathogenesis that currently has no cure. α7 nicotinic acetylcholine receptor (α7nAChR) is known to regulate multiple aspects of immune function. The present study aimed to evaluate the protective effects
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