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文件

安全信息

M2028

Sigma-Aldrich

辣椒素

≥95%, from Capsicum sp.

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别名:
8-甲基-N-香草基-反-6-壬烯胺
线性分子式:
(CH3)2CHCH=CH(CH2)4CONHCH2C6H3-4-(OH)-3-(OCH3)
CAS号:
404-86-4
分子量:
305.41
Beilstein:
2816484
EC 号:
206-969-8
MDL编号:
MFCD00017259
UNSPSC代码:
12352200
PubChem化学物质编号:
24896598
NACRES:
NA.77

生物来源

Capsicum sp.

质量水平

200

检测方案

≥95%

mp

62-65 °C (lit.)

溶解性

H2O: insoluble
ethanol: soluble

储存温度

2-8°C

SMILES字符串

COc1cc(CNC(=O)CCCC\C=C\C(C)C)ccc1O

InChI

1S/C18H27NO3/c1-14(2)8-6-4-5-7-9-18(21)19-13-15-10-11-16(20)17(12-15)22-3/h6,8,10-12,14,20H,4-5,7,9,13H2,1-3H3,(H,19,21)/b8-6+

InChI key

YKPUWZUDDOIDPM-SOFGYWHQSA-N

基因信息

human ... CYP1A2(1544) , TRPV1(7442)
rat ... Trpv1(83810) , Trpv4(66026)

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一般描述

Capsaicin is an alkaloid that is present inthe fruit of the Capsicum genus and is the main reason for the spicy flavor inhot peppers including jalapenos, habaneros, and red chili peppers. It isobserved that capsaicin acts as a chemoprotective agent and can induceapoptosis, inhibit proliferation, and induce cell-cycle arrest in variouscancer cells. Capsaicin activates its receptor transient receptorpotential vanilloid subfamily member 1 (TRPV1) and activates sensory afferentneurons that causes neurogenicinflammation, hypothermia, and pain.

应用

辣椒素已被用于：
  • 研究其对与突触可塑性相关的染色质重塑和基因表达的影响
  • 研究H2C1细胞（表达TRPV1通道的人胚肾293细胞）中的TRPV1通道信号

Capsaicin has also been used asa TRPV1 agonist to study the effect of barbamide on capsaicin response indorsal root ganglion sensory neurons.

生化/生理作用

原型香草受体激动剂。 神经毒素；激活产生无髓C纤维的感觉神经元，其中许多含有P物质。 局部使用可使感觉神经末梢脱敏，从而产生反常的抗伤害感受作用；全身给药可对辣椒素敏感的细胞产生神经毒性，尤其是在新生动物中。辣椒的活性成分。

警示用语：

Danger

危险分类

Acute Tox. 2 Oral - Eye Dam. 1 - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3

靶器官

Respiratory system

WGK

WGK 3

闪点(°F)

235.4 °F

闪点(°C)

113 °C

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

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    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

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Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice.
Wang S, et al.
Experimental & Molecular Medicine, 50(3), e455-e455 (2018)
Surinder Kumar Sharma et al.
European journal of pharmacology, 720(1-3), 55-62 (2013-11-12)
Capsaicin is the active ingredient of chili peppers and gives them the characteristic pungent flavor. Understanding the actions of capsaicin led to the discovery of its receptor, transient receptor potential vanilloid subfamily member 1 (TRPV1). This receptor is found on
Ann M Bode et al.
Cancer research, 71(8), 2809-2814 (2011-04-14)
Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) is the principal pungent component in hot peppers, including red chili peppers, jalapeños, and habaneros. Consumed worldwide, capsaicin has a long and convoluted history of controversy about whether its consumption or topical application is entirely safe. Conflicting epidemiologic
Stimulation of TRPV1 channels activates the AP-1 transcription factor.
Backes TM, et al.
Biochemical Pharmacology, 150(3), 160-169 (2018)
Chemical and Pharmacological Aspects of Capsaicin
Maria D, et al.
Molecules (Basel), 16(2), 1253-1270 (2011)
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