M1818
莫林酮 盐酸盐
≥98% (HPLC), solid
别名:
3-Ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4H-indol-4-one hydrochloride
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选择尺寸
关于此项目
经验公式（希尔记法）:
C16H24N2O2 · HCl
化学文摘社编号:
分子量:
312.83
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
InChI
1S/C16H24N2O2.ClH/c1-3-13-11(2)17-14-5-4-12(16(19)15(13)14)10-18-6-8-20-9-7-18;/h12,17H,3-10H2,1-2H3;1H
SMILES string
CCC1=C(C)NC2=C1C(C(CN3CCOCC3)CC2)=O.Cl
InChI key
GQWNECFJGBQMBO-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
solid
color
off-white
solubility
H2O: 19 mg/mL
originator
Endo
Quality Level
Gene Information
human ... DRD2(1813), HTR2A(3356), MAOA(4128), MAOB(4129)
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Biochem/physiol Actions
D2 dopamine receptor antagonist; MAO inhibitor.
Features and Benefits
This compound was developed by Endo. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 3 Oral
存储类别
6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
法规信息
新产品
此项目有
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Excessive body weight gain (BWG) is a common side effect of some typical and atypical antipsychotic drugs (APs). Convergent evidence suggests a hierarchy in the magnitude of BWG that may be induced by diverse agents, being very high for clozapine
Jennifer Dugan Stocks et al.
Journal of child and adolescent psychopharmacology, 22(2), 102-111 (2012-03-01)
To evaluate safety and tolerability of four doses of immediate-release molindone hydrochloride in children with attention-deficit/hyperactivity disorder (ADHD) and serious conduct problems. This open-label, parallel-group, dose-ranging, multicenter trial randomized children, aged 6-12 years, with ADHD and persistent, serious conduct problems
Could repetitive transcranial magnetic stimulation improve neurocognition in early-onset schizophrenia spectrum disorders?
Paul E Croarkin et al.
Journal of the American Academy of Child and Adolescent Psychiatry, 51(9), 949-951 (2012-08-25)
C Recasens
L'Encephale, 27(3), 269-276 (2001-08-08)
Weight gain associated with neuroleptics or antipsychotic treatment is well known by psychiatrists, but is too rarely considered as justifying a specific treatment program. Overweight is a risk factor for somatic disorders and can have a negative influence on self-esteem
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