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安全信息

M1778

Sigma-Aldrich

黏液蛋白 来源于猪胃

Type III, bound sialic acid 0.5-1.5 %, partially purified powder

别名:

MUC

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About This Item

CAS号:
84082-64-4
EC 号:
282-010-7
MDL编号:
MFCD00131629
UNSPSC代码:
12352202
NACRES:
NA.61

生物来源

Porcine stomach

质量水平

200

类型

Type III

形式

partially purified powder

组成

bound sialic acid, 0.5-1.5%

技术

microbiological culture: suitable

溶解性

NaOH: soluble 20 mg/mL

储存温度

2-8°C

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相关类别

一般描述

黏液蛋白或黏液糖蛋白是哺乳动物黏液的主要大分子成分。它还被应用于评价细胞离心浓缩痰涂片检测抗酸杆菌的研究。

应用

猪胃黏液素已应用于 铜绿假单胞菌半乳糖特异性凝集素PA-IL结合位点的研究。

生化/生理作用

黏液形成所有上皮表面的保护层。黏液的主要结构成分是形成凝胶的黏液素。覆盖肠上皮的黏液层以MUC2粘蛋白为中心分子。MUC2是由杯状细胞产生。

制备说明

根据Glenister等人的方法制备而得，用于牙菌斑细菌的复杂生长培养基。

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

动植物源性产品

分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What does the "Type" designation in Mucin from porcine stomach mean?

    The type designation does not have any particular biological significance.  It is used to emphasize differences in the listings of this product.

  6. Is Product M1778, Mucin from porcine stomach, a purified preparation of mucin?

    This product is a partially purified preparation of mucin based on the method of Glenister cited on the product's webpage.

  7. How can I solubilize Product M1778, Mucin from porcine stomach?

    Mucin is not readily soluble in aqueous solutions. Turbid "solutions" will form at about 5 mg/mL in 0.1 M acetate buffer, pH 5.0. To try to increase the solubility, one might try further dilution and sonication, but we have not tried this in our labs.

  8. What is the molecular weight of Product M1778, Mucin from porcine stomach?

    This product is partially purified from crude mucin, M2378.  Sigma has not determined the molecular weight of this product. Neither has the sugar and amino acid composition been determined.

  9. What are the differences between Mucin from porcine stomach Products M2378 and M1778?

    Product No. M2378 is a crude mucin preparation. Product No. M1778 is a partially purified powder prepared according to the method described in Glenister, D.A. and Salmon. K. Microbial Ecol. in Health & Disease 1, 31, (1988). The amount of bound sialic acids are also different. Please refer to the specification sheets on our website.

  10. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Leyuan Li et al.
Microbiome, 8(1), 33-33 (2020-03-13)
Human-targeted drugs may exert off-target effects or can be repurposed to modulate the gut microbiota. However, our understanding of such effects is limited due to a lack of rapid and scalable assay to comprehensively assess microbiome responses to drugs. Drugs
Kenny C Mok et al.
mBio, 11(6) (2020-12-10)
The beneficial human gut bacterium Akkermansia muciniphila provides metabolites to other members of the gut microbiota by breaking down host mucin, but most of its other metabolic functions have not been investigated. A. muciniphila strain MucT is known to use
Abiodun D Ogunniyi et al.
PloS one, 13(7), e0200195-e0200195 (2018-07-17)
There are very few articles in the literature describing continuous models of bacterial infections that mimic disease pathogenesis in humans and animals without using separate cohorts of animals at each stage of disease. In this work, we developed bioluminescent mouse
Francisco J Alvarez et al.
Applied and environmental microbiology, 81(8), 2770-2780 (2015-02-11)
The pathogenic fungus Candida albicans is the leading cause of vulvovaginal candidiasis (VVC). VVC represents a major quality-of-life issue for women during their reproductive years, a stage of life where the vaginal epithelium is subject to periodic hormonally induced changes
C A Saceanu et al.
Journal of clinical microbiology, 31(9), 2371-2374 (1993-09-01)
Early identification and isolation of tuberculosis patients is of utmost importance to minimize the risk of further epidemic spread of the disease. The traditional concentrated acid-fast smears are not very reliable tools for the presumptive diagnosis of tuberculosis. Acid-fast bacillus
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