所有图片(1)
About This Item
经验公式（希尔记法）:
C9H12NO5P
CAS号:
分子量:
245.17
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
质量水平
检测方案
≥97% (NMR)
形式
solid
颜色
off-white
溶解性
DMSO: <4 mg/mL
H2O: <4 mg/mL
SMILES字符串
CC(N)(C(O)=O)c1ccc(cc1)P(O)(O)=O
InChI
1S/C9H12NO5P/c1-9(10,8(11)12)6-2-4-7(5-3-6)16(13,14)15/h2-5H,10H2,1H3,(H,11,12)(H2,13,14,15)
InChI key
PAONCRJPUQXPRW-UHFFFAOYSA-N
生化/生理作用
Group III/II metabotropic glutamate (mGluR) receptor antagonist.
特点和优势
This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
T E Salt et al.
Neuropharmacology, 35(2), 239-241 (1996-02-01)
The metabotropic glutamate receptor (mGluR) agonists CCG-I and L-AP4, acting at Group II and Group III mGluRs respectively, can reduce GABAergic synaptic inhibition on single neurones in the rat thalamus in vivo via a presumed presynaptic mechanism. The actions of
Gelareh Abulwerdi et al.
Neurochemistry international, 138, 104770-104770 (2020-05-27)
Chronic dysregulated microglial activation may lead to persistent inflammation and progressive neurodegeneration. A previous study reported that ADX88178, a putative metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulator (PAM), exerts anti-inflammatory effects in microglia by activating mGluR4. We employed in
Bruce A Collings
Rapid communications in mass spectrometry : RCM, 33(10), 914-924 (2019-03-12)
Quadrupole pre-filter transmission profiles are shown to be affected by the presence of trapped ions within the pre-filter of a quadrupole mass spectrometer. Trapped ions are the result of ions reflected at the pre-filter/mass filter boundary and lead to space
H N David et al.
Neuropharmacology, 44(6), 717-727 (2003-04-12)
Previous investigations have shown that mGlu receptors would be involved in the amphetamine-induced motor response. However, data are somewhat controversial across studies where methodological protocols vary. The aim of the present study was to determine the involvement of mGlu receptors
T Kral et al.
Synapse (New York, N.Y.), 47(4), 278-284 (2003-01-23)
Activation of presynaptic metabotropic glutamate receptors (mGluRs) leads to a powerful inhibition of glutamate release from many synaptic terminals throughout the CNS. mGluRs as autoreceptors are believed to provide a negative feedback system that prevents potentially toxic accumulation of glutamate
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