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Merck
CN

M157

MEN-10,376

≥95% (HPLC), solid

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关于此项目

经验公式(希尔记法):
C57H68N12O10
化学文摘社编号:
分子量:
1081.22
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Form:
solid
Assay:
≥95% (HPLC)
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产品名称

MEN-10,376, ≥95% (HPLC), solid

InChI

1S/C57H68N12O10/c1-31(2)50(69-56(78)48(26-35-30-63-43-16-8-5-13-39(35)43)67-53(75)45(23-32-18-20-36(70)21-19-32)65-52(74)40(59)27-49(71)72)57(79)68-47(25-34-29-62-42-15-7-4-12-38(34)42)55(77)66-46(24-33-28-61-41-14-6-3-11-37(33)41)54(76)64-44(51(60)73)17-9-10-22-58/h3-8,11-16,18-21,28-31,40,44-48,50,61-63,70H,9-10,17,22-27,58-59H2,1-2H3,(H2,60,73)(H,64,76)(H,65,74)(H,66,77)(H,67,75)(H,68,79)(H,69,78)(H,71,72)

SMILES string

CC(C)C(NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc3ccc(O)cc3)NC(=O)C(N)CC(O)=O)C(=O)NC(Cc4c[nH]c5ccccc45)C(=O)NC(Cc6c[nH]c7ccccc67)C(=O)NC(CCCCN)C(N)=O

InChI key

QQHOFZNACVKNHK-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

solid

color

white

storage temp.

−20°C

Quality Level

Gene Information

human ... TACR2(6865)

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Biochem/physiol Actions

Potent and selective NK-2 tachykinin receptor antagonist.

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

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分析证书(COA)

Lot/Batch Number

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M W Lewis et al.
American journal of physiology. Gastrointestinal and liver physiology, 281(1), G164-G172 (2001-06-16)
Previous evidence suggests that substance P (SP) activates subpopulations of neurons within the dorsal motor nucleus of the vagus (DMV). In this study we aimed at identifying these subpopulations in relation to their gastrointestinal projection organs or vagal branches and
Monika Sundqvist et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 291(4), R1138-R1144 (2006-05-20)
The transparent body wall of Xenopus laevis larvae during the first developmental stages allows in vivo studies of gastrointestinal tract activity. The purpose of this study was to chart the ontogeny of gut motility in Xenopus larvae and to identify
Kyle M Baumbauer et al.
Behavioral neuroscience, 121(5), 1082-1094 (2007-10-03)
Previous research has demonstrated that spinally transected rats can acquire a prolonged flexion response to prevent the delivery of shock. However, rats that receive shock irrespective of leg position cannot learn to maintain the same response. The present experiments examined
Donatella Mutolo et al.
Journal of applied physiology (Bethesda, Md. : 1985), 109(4), 1002-1010 (2010-07-24)
We have previously shown that the caudal nucleus tractus solitarii is a site of action of some antitussive drugs and that the caudal ventral respiratory group (cVRG) region has a crucial role in determining both the expiratory and inspiratory components
Donatella Mutolo et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 295(1), R243-R251 (2008-05-16)
We have previously shown that ionotropic glutamate receptors in the caudal portion of the nucleus tractus solitarii (NTS), especially in the commissural NTS, play a prominent role in the mediation of tracheobronchial cough and that substance P potentiates this reflex.

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