M1387
4-甲基吡唑 盐酸盐
alcohol dehydrogenase inhibitor
别名:
甲吡唑
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关于此项目
经验公式（希尔记法）:
C4H6N2 · HCl
化学文摘社编号:
分子量:
118.56
NACRES:
NA.77
PubChem Substance ID:
MDL number:
UNSPSC Code:
12352100
InChI
1S/C4H6N2.ClH/c1-4-2-5-6-3-4;/h2-3H,1H3,(H,5,6);1H
SMILES string
Cl.Cc1cn[nH]c1
InChI key
PUCXJHNDMYZOHG-UHFFFAOYSA-N
biological source
synthetic (organic)
assay
≥95%
form
powder
mp
157-159 °C
solubility
methanol: 100 mg/mL, clear, colorless to yellow
storage temp.
2-8°C
Quality Level
Gene Information
human ... ADH1A(124), ADH1B(125), ADH1C(126)
相关类别
Application
Useful as an antidote in methanol and ethylene glycol poisoning.
4-Methylpyrazole hydrochloride has been used:
- as a cytochrome P450 2E1 inhibitor
- as cytochrome P450 2E1 and alcohol dehydrogenase inhibitor in 1C11 neural progenitor cells
- to inhibit ethanol oxidation in VL-17A cells expressing alcohol dehydrogenase and HepG2 cells
Biochem/physiol Actions
4-Methylpyrazole (4MP) inhibits ethanol oxidation in liver microsomes. It also blocks the c-Jun N-terminal kinase (JNK) activation in in vitro liver injury models.
醇脱氢酶抑制剂
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Mohan S Maddur et al.
Clinical reviews in allergy & immunology, 58(2), 213-228 (2019-06-05)
Natural antibodies (nAbs) are most commonly defined as immunoglobulins present in the absence of pathological conditions or deliberate immunizations. Occurrence of nAbs in germ- and antigen-free mice suggest that their production is driven, at least in part, by self-antigens. Accordingly
Graham A Tipples et al.
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 30(3), 233-238 (2004-05-12)
Rubella virus generally causes a mild fever, rash illness similar in clinical presentation to infections by other viruses including measles and parvovirus B19. Rubella infections in pregnant women in the first trimester carry a high risk of congenital rubella syndrome
Raido Paasma et al.
Clinical toxicology (Philadelphia, Pa.), 50(9), 823-831 (2012-09-21)
INTRODUCTION. Thorough prognostic and metabolic studies of methanol poisonings are scarce. Our aims were to evaluate the factors associated with sequelae and death from methanol poisoning, to develop a simple risk-assessment chart to evaluate factors associated with sequelae and death
Trang T T Nguyen et al.
Critical reviews in immunology, 36(2), 163-177 (2016-12-03)
Most serum immunoglobulin M (IgM) is "natural IgM", which is produced apparently spontaneously by a distinct subset of B cells requiring no exogenous antigenic or microbial stimuli. Natural IgM is an evolutionarily conserved molecule and reacts with a variety of
D E Feierman et al.
The Biochemical journal, 239(3), 671-677 (1986-11-01)
Pyrazole and 4-methylpyrazole, which are inhibitors of alcohol dehydrogenase, were also found to be effective inhibitors of the oxidation of ethanol by liver microsomes (microsomal fractions) in vitro. Ethanol oxidation by microsomes from rats previously treated for 2 or 3
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