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描述
Relative stereochemistry
Store with desiccants
质量水平
方案
≥98% (HPLC)
表单
solid
颜色
white
溶解性
H2O: 19 mg/mL
创始人
Cypress Bioscience
储存温度
2-8°C
SMILES字符串
Cl[H].CCN(CC)C(=O)[C@@]1(C[C@@H]1CN)c2ccccc2
InChI
1S/C15H22N2O.ClH/c1-3-17(4-2)14(18)15(10-13(15)11-16)12-8-6-5-7-9-12;/h5-9,13H,3-4,10-11,16H2,1-2H3;1H/t13-,15+;/m1./s1
InChI key
XNCDYJFPRPDERF-PBCQUBLHSA-N
生化/生理作用
Serotonin and norepinephrine reuptake inhibitor (SNRI)
特点和优势
This compound was developed by Cypress Bioscience. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
J Maj et al.
Journal of neural transmission (Vienna, Austria : 1996), 107(11), 1345-1359 (2001-01-06)
Milanacipran (MIL) is a representative of a new class of antidepressants (SNRIs) which inhibit selectively the reuptake of serotonin and noradrenaline but, in contrast to tricyclics, show no affinity for neurotransmitter receptors. The present study was aimed at determining whether
Hiroshi Kawai et al.
Biological & pharmaceutical bulletin, 41(2), 213-219 (2018-02-02)
Biological rhythms are thought to be related to the pathogenesis and therapy of various diseases including depression. Here we investigated the influence of circadian rhythms on the antidepressant activity of the dual-action serotonin-noradrenaline reuptake inhibitor (SNRI) milnacipran. Rats administered milnacipran
Junji Uno et al.
Pharmacology, 99(1-2), 89-98 (2016-10-25)
To investigate the potential inhibitory effects of 18 clinically available antidepressants on acetylcholine (ACh)-induced contractions in guinea pig urinary bladder smooth muscle (UBSM) in order to predict whether they may induce voiding impairment. Concentration-response curves for ACh-induced contractions in guinea
P Okkerse et al.
European journal of pain (London, England), 21(3), 494-506 (2016-09-22)
Serotonin-norepinephrine reuptake inhibitors inhibit the reuptake of serotonin and noradrenalin and are used in the treatment of neuropathic pain. Animal studies suggest that milnacipran co-administered with opioids may potentiate the analgesic effect of μ-opioid receptor agonists. This study hypothesized that
Tsugunobu Andoh et al.
Biological & pharmaceutical bulletin, 43(7), 1111-1117 (2020-07-03)
Patients with cholestatic liver diseases, such as primary biliary cirrhosis, usually suffer from pruritus. However, the pathogenesis of cholestatic pruritus is unclear, and there is no current effective treatment for it. In order to find a treatment for the condition
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