Anti-Mucolipin-2 (C-terminal) 兔抗

Mucolipin-2 (MLN2) is a member of transient receptor potential (TRP) protein superfamily. It consists of gated, tetrameric cation channels. MLN2 has a conserved structure of six transmembrane helices with differing cytoplasmic oriented N- and C-terminal domains. It is localized to late endosomes and lysosomes..

Additional bands may be observed at ~120 kDa and ~35 kDa due to aggregation and degradation, respectively.

synthetic peptide corresponding to amino acids 534-549 of human mucolipin-2. This sequence has low homology with rat (73% identity) and mouse (66% homology) mucolipin-2.

Anti-Mucolipin-2 (C-terminal) antibody produced in rabbit has been used in immunoblotting.

Mucolipin-2 (MLN2) plays an important role in lysosome maturation, lysosome fission, late endosome-lysosome fusion, autophagosome-lysosome fusion, lysosome expulsion and iron release. It stimulates autophagy proliferation via transcription factor EB (TFEB) activation. MLN2 is involved in B‐lymphocyte development.

0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。

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