所有图片(1)
About This Item
经验公式（希尔记法）:
C13H17N · HCl
CAS号:
分子量:
223.74
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
推荐产品
表单
solid
质量水平
颜色
white
溶解性
H2O: soluble
ethanol: soluble
SMILES字符串
Cl[H].CN1CCC(=CC1)c2ccccc2C
InChI
1S/C13H17N.ClH/c1-11-5-3-4-6-13(11)12-7-9-14(2)10-8-12;/h3-7H,8-10H2,1-2H3;1H
InChI key
QLIQCKBPYIWPTE-UHFFFAOYSA-N
应用
1-甲基-4-(2′-甲基苯基)-1,2,3,6-四氢吡啶盐酸盐已被用于研究其对C57BL/6J 小鼠核心温度的影响。
生化/生理作用
1-甲基-4-(2′-甲基苯基)-1,2,3,6-四氢吡啶盐酸盐（MPTP）是一种叔胺。它广泛应用于诱导小鼠的实验性帕金森病。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
个人防护装备
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
法规信息
新产品
F F Cruz-Sanchez et al.
Molecular and chemical neuropathology, 19(1-2), 163-176 (1993-05-01)
In order to compare the recovery capacity of the nigrostriatal system between adult and old mice, MPTP hydrochloride was administered to 48 BL/C57 male mice, which were sacrificed 24 h or 10 d after the second dose. The animals were
T May
Neuroscience letters, 162(1-2), 55-58 (1993-11-12)
The in vitro binding of [3H]pargyline and [3H]harman ([3H]1-methyl-beta-carboline) to monoamine oxidase A (MAO-A; EC 1.4.3.4) on membranes of rat cerebral cortex was evaluated. Displacement of the [3H]pargyline binding on MAO-A (L(-)-deprenyl suppressed binding to MAO-B) by harman, 1-methyl-4-phenylpyridinium (MPP+)
N Yoshimura et al.
Neuropharmacology, 32(4), 315-321 (1993-04-01)
A pharmacological study using monkeys, in which parkinsonism was induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), was undertaken to elucidate the mechanism underlying urinary bladder dysfunctions in Parkinson's disease. Under ketamine anesthesia, cystometrograms showed that, in MPTP-treated monkeys, a contraction of the urinary
Voloshin MYa et al.
Neuroscience, 53(3), 845-854 (1993-04-01)
Activity of entopeduncular neurons was studied in chronic experiments on cats during performance of instrumental movement: pedal pressing and holding. One-hundred and twenty-four neurons were extracellularly investigated in intact animals and 81 neurons in cats treated with N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) (5
P K Sonsalla et al.
The Journal of pharmacology and experimental therapeutics, 242(3), 850-857 (1987-09-01)
1-Methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'CH3-MPTP) was shown previously to be a more potent neurotoxicant than 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice. The present investigation was conducted to determine possible reasons for the greater potency of 2'CH3-MPTP and to determine if its neurotoxic action might be
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