M0883
4-Methylumbelliferyl acetate
esterase substrate
别名:
MU-Ac
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关于此项目
经验公式（希尔记法）:
C12H10O4
化学文摘社编号:
分子量:
218.21
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
EC Number:
220-386-6
Beilstein/REAXYS Number:
189667
MDL number:
InChI key
HXVZGASCDAGAPS-UHFFFAOYSA-N
InChI
1S/C12H10O4/c1-7-5-12(14)16-11-6-9(15-8(2)13)3-4-10(7)11/h3-6H,1-2H3
SMILES string
CC(=O)Oc1ccc2C(C)=CC(=O)Oc2c1
assay
≥98% (TLC)
form
powder
mp
149-150 °C (lit.)
solubility
chloroform: 100 mg/mL, clear, colorless
fluorescence
λex 312 nm in methanol, λex 360 nm; λem 499 nm (Reaction product)
storage temp.
−20°C
Quality Level
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
H G Raj et al.
Teratogenesis, carcinogenesis, and mutagenesis, 21(2), 181-187 (2001-02-27)
Our earlier studies documented the ability of 7,8-diacetoxy-4-methylcoumarin (DAMC) to cause irreversible inhibition of cytochrome P-450 linked mixed function oxidases (MFO) mediated by membrane bound DAMC: protein transacetylase. Since P-450 catalyzed oxidation of benzene is crucial to its toxic effects
A A Frimer et al.
Free radical biology & medicine, 20(6), 843-852 (1996-01-01)
--2-(Dimethylamino) fluorene (1a) and 5-benzoyloxy-2,3,7,8,12,13,17,18-octaethylporphyrin (4) react with superoxide anion radical (generated from KO2/18-crown-6 polyether) in aprotic media. Yet, when incorporated into the lipid bilayer of dimyristoyl phosphatidylcholine liposomes, these two substrates are inert to superoxide, generated enzymatically (xanthine oxidase/acetaldehyde)
Enzyme kinetic studies in cell populations using fluorogenic substrates and flow cytometric techniques.
J V Watson
Cytometry, 1(2), 143-151 (1980-09-01)
M L Graber et al.
The American journal of physiology, 250(1 Pt 2), F159-F168 (1986-01-01)
Intracellular pH (pHi) of turtle bladder mucosal cells was studied by the trapped fluorescent indicator technique. Bladders efficiently accumulated and converted 4-methylumbelliferyl acetate to its pH-sensitive derivative 4-methylumbelliferone (4MU). Excited at the pH-indifferent wavelength 334 nm, bladders fluoresced a uniform
Wanlapa Chaibangyang et al.
The Korean journal of parasitology, 55(6), 643-652 (2018-01-13)
Calreticulin (CALR), a multifunctional protein thoroughly researched in mammals, comprises N-, P-, and C-domain and has roles in calcium homeostasis, chaperoning, clearance of apoptotic cells, cell adhesion, and also angiogenesis. In this study, the spatial and temporal expression patterns of
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