生物来源
rabbit
质量水平
偶联物
unconjugated
抗体形式
IgG fraction of antiserum
抗体产品类型
primary antibodies
克隆
polyclonal
形式
buffered aqueous solution
分子量
antigen 40 kDa
种属反应性
mouse, rat
技术
microarray: suitable
western blot: 1:10,000 using NIH3T3 mouse fibroblast lysate and rat brain extract
UniProt登记号
运输
dry ice
储存温度
−20°C
靶向翻译后修饰
unmodified
基因信息
human ... MAPK1(5594)
mouse ... Mapk1(26413)
rat ... Mapk1(116590)
一般描述
P38 MAPK是丝氨酸/苏氨酸蛋白激酶家族的丝裂原活化蛋白激酶（MAPK），在渗透压变化、紫外线照射、热休克、细胞因子和脂多糖（LPS）等应激信号的作用下被激活。主要表达于脑、肌肉、胸腺、脾、心、肺、肾和成纤维细胞。
特异性
兔抗p38MAP激酶抗体可与小鼠和大鼠的p38MAP激酶发生特异性反应。
免疫原
源自小鼠p38MAP激酶（氨基酸343-360，N端添加赖氨酸）C端的合成肽K-DEVISFVPPPLDQEEMES作为免疫原。 该序列在人和大鼠p38MAP激酶中高度保守。
应用
抗p38MAP激酶抗体已用于使用NIH 3T3小鼠成纤维细胞裂解物和大鼠脑提取物的蛋白质印迹法（1：1000稀释）。它也用于微阵列。
生化/生理作用
丝裂原活化蛋白激酶（MAP激酶，MAPKs）是蛋白激酶家族，被认为通过将有丝分裂信号引导至其细胞内靶标，在哺乳动物细胞的信号转导途径中起关键作用。MAP激酶调节多种细胞过程，例如增殖，分化，应激反应和肿瘤发生。p38 MAPK被激活以响应应激信号-渗透压变化，紫外线辐射，热休克，细胞因子和脂多糖（LPS）。它是MAPK激活的蛋白激酶2（MAPKAPK-2）磷酸化所必需的。抗p38MAP激酶抗体可用于研究正常组织和肿瘤组织中MAP激酶亚型的差异组织表达、特异性活化要求和细胞内定位。
外形
0.01M 磷酸缓冲盐溶液，pH 7.4，含 15mM 叠氮化钠。
免责声明
除非我们的产品目录或产品附带的其他公司文档另有说明，否则我们的产品仅供研究使用，不得用于任何其他目的，包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。
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WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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