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Merck
CN

M076000

Sigma-Aldrich

Sulfur 42

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别名:
Phenyl-3H-1,2,4-dithiazol-3-one
经验公式(希尔记法):
C8H5NOS2
CAS号:
分子量:
195.26
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.03

类型

for DNA synthesis

质量水平

产品线

Proligo Reagents

检测方案

≥99.0% (reversed phase HPLC)

形式

solid

包装

pkg of 1 g M076000-1G
2 g of 2 g M076000-2G

杂质

≤0.1% water content (Karl Fischer)

颜色

faintly yellow to yellow

溶解性

acetonitrile: 0.1 M, clear

适用性

conforms to structure for H-NMR

储存温度

2-8°C

SMILES字符串

O=C1SSC(C2=CC=CC=C2)=N1

InChI

1S/C8H5NOS2/c10-8-9-7(11-12-8)6-4-2-1-3-5-6/h1-5H

InChI key

LKDWQHQNDDNHSC-UHFFFAOYSA-N

一般描述

Sulfur 42 is a sulfurization reagent.

应用

Sulfur 42 is suitable for use instead of an Oxidizer during the synthesis cycle to manufacture thioated oligonucleotides.

特点和优势

  • Sulfur 42 is at least 4 times more reactive than Beaucage reagent or PADS
  • Crystalline powder
  • Odourless, no foul smell
  • Solubility in ACN up to 0.28M at (+10 °C); no need to applied a co-solvent like in DCM, THF
  • The solvent for the dissolution of the reagent should be dry (< 50 ppm) in order to minimize P=O impurities
  • Stable in ACN solution for at least 21 days
  • Recommended reaction time for the sulfurization in oligonucleotide synthesis for a 0.1M solution is 60 sec

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable


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