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一般描述
Myelin basic protein (MBP) is an 18.5kDa protein encoded by the gene mapped to human chromosome 18q22qter. MBP is a major component of myelin sheath and is highly expressed in central nervous system (CNS).
应用
Myelin basic protein antigen from human brain has been used in enzyme-linked immunosorbent spot assays.
生化/生理作用
Myelin basic protein (MBP) plays a vital role in formation of myelin sheath and is associated with the various neurological disorders. MBP function as an antigenic target in autoimmune disease experimental allergic encephalomyelitis (EAE). It also has a crucial role to play in human demyelinating diseases including multiple sclerosis (MS). MBP plays an essential role in cytoskeletal turnover and membrane extension. Additionally, it is also involved in Fyn-mediated signaling pathways, sequestration of phosphoinositides and regulation of calcium homoeostasis.
Determined using polyclonal and monoclonal antibodies against MBP.
外形
Lyophilized from 10mM HCl.
其他说明
Blood samples from donors were tested and found to be negative for HBsAg, HIV-1 and HIV-2 antibodies, HCV.
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
法规信息
常规特殊物品
Localization of the human myelin basic protein gene (MBP) to region 18q22----qter by in situ hybridization.
Saxe DF
Cytogenetics and Cell Genetics, 39(4), 246-249 (1985)
Distinct T cell signatures define subsets of patients with multiple sclerosis.
Johnson MC
Neurology? neuroimmunology & neuroinflammation, 3(5), e278-e278 (2016)
MyelStones: the executive roles of myelin basic protein in myelin assembly and destabilization in multiple sclerosis.
Vassall KA
The Biochemical Journal, 472(1), 17-32 (2015)
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