form
liquid
Quality Level
concentration
~40% (enzymatic), ~40% in H2O
density
1.17 g/mL at 25 °C (lit.)
storage temp.
2-8°C
SMILES string
[H]C(=O)C(C)=O
InChI
1S/C3H4O2/c1-3(5)2-4/h2H,1H3
InChI key
AIJULSRZWUXGPQ-UHFFFAOYSA-N
General description
甲基乙二醛（MG）是一种葡萄糖代谢物，其与糖尿病患者的周围神经病和疼痛相关。它可上调感觉神经元中的细胞内钙并产生行为伤害感受。甲基乙二醛具有抗菌性。MG可作为蛋白-糖化剂和晚期糖基化终产物的前体。它会损害糖尿病伤口的愈合。
Application
甲基乙二醛溶液已用于：
- 评估乙二醛酶1 (GLO1)的酶活性
- 在体外作为制备白蛋白的晚期糖基化终末（AGE）形成剂
- 调节小鼠焦虑样行为
- 诱导大鼠腹膜纤维化
- 研究有机化学品和金属DNA加合物的色谱保留特性
- 用于小鼠足底内注射以研究甲基乙二醛（MG）-瞬时受体电位锚蛋白1（TRPA1）-腺苷酸环化酶1同种型（AC1）途径的外周和中心组成
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signalword
Danger
hcodes
Hazard Classifications
Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
存储类别
10 - Combustible liquids
商品
High-Performance Thin-Layer chromatography (HPTLC) quantification of methylglyoxal (MGO) in complex and matrix rich manuka honey offering quick sample preparation, high-matrix tolerance, and high-throughput.
Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice
McMurray KMJ, et al.
Behavioural Brain Research, 301, 119-123 (2016)
Measurement of the modification and interference rate of urinary albumin detected by size-exclusion HPLC
Marko L, et al.
Physiological Measurement, 30(10), 1137-1137 (2009)
Regular and moderate exercise counteracts the decline of antioxidant protection but not methylglyoxal-dependent glycative burden in the ovary of reproductively aging mice
Falone S, et al.
Oxidative Medicine and Cellular Longevity, 2016 (2016)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| M0252-1L | 04061837841026 |
| M0252-25ML | 04061833992784 |
| M0252-500ML | 04061837841040 |
| M0252-100ML | 04061833992777 |
| M0252-250ML | 04061837841033 |