所有图片(1)
别名:
2-氧代丙醛, Pyruvaldehyde, 丙酮醛
线性分子式:
CH3COCHO
CAS号:
分子量:
72.06
Beilstein:
906750
MDL编号:
UNSPSC代码:
12352204
PubChem化学物质编号:
NACRES:
NA.32
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一般描述
甲基乙二醛（MG）是一种葡萄糖代谢物，其与糖尿病患者的周围神经病和疼痛相关。它可上调感觉神经元中的细胞内钙并产生行为伤害感受。甲基乙二醛具有抗菌性。MG可作为蛋白-糖化剂和晚期糖基化终产物的前体。它会损害糖尿病伤口的愈合。
应用
甲基乙二醛溶液已用于：
- 评估乙二醛酶1 (GLO1)的酶活性
- 在体外作为制备白蛋白的晚期糖基化终末（AGE）形成剂
- 调节小鼠焦虑样行为
- 诱导大鼠腹膜纤维化
- 研究有机化学品和金属DNA加合物的色谱保留特性
- 用于小鼠足底内注射以研究甲基乙二醛（MG）-瞬时受体电位锚蛋白1（TRPA1）-腺苷酸环化酶1同种型（AC1）途径的外周和中心组成
警示用语：
Danger
危险分类
Eye Dam. 1 - Met. Corr. 1 - Muta. 2 - Skin Sens. 1
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Neuronal overexpression of Glo1 or amygdalar microinjection of methylglyoxal is sufficient to regulate anxiety-like behavior in mice
McMurray KMJ, et al.
Behavioural Brain Research, 301, 119-123 (2016)
Measurement of the modification and interference rate of urinary albumin detected by size-exclusion HPLC
Marko L, et al.
Physiological Measurement, 30(10), 1137-1137 (2009)
Regular and moderate exercise counteracts the decline of antioxidant protection but not methylglyoxal-dependent glycative burden in the ovary of reproductively aging mice
Falone S, et al.
Oxidative Medicine and Cellular Longevity, 2016 (2016)
Methylglyoxal requires AC1 and TRPA1 to produce pain and spinal neuron activation
Griggs RB, et al.
Frontiers in Neuroscience, 11, 679-679 (2017)
The Therapeutic Potential of Human Umbilical Mesenchymal Stem Cells From Wharton's Jelly in the Treatment of Rat Peritoneal Dialysis-Induced Fibrosis
Fan YP, et al.
Stem Cells Translational Medicine, 5(2), 235-247 (2016)
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