M024080
ssH-Linker
configured for PerkinElmer, configured for Polygen
别名:
9,11-Dioxa-2-aza-10-phosphatridecanoic acid, 10-[bis(1-methylethyl)amino]-13-cyano-, 2-[[(4-methoxyphenyl)diphenylmethyl]amino]ethyl este
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所有图片(1)
About This Item
经验公式（希尔记法）:
C38H53N4O5P
分子量:
676.83
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.51
类型
for DNA synthesis
质量水平
产品线
Proligo Reagents
检测方案
≥98% (31P-NMR)
≥98.0% (reversed phase HPLC)
相容性
configured for PerkinElmer
configured for Polygen
储存温度
−20°C
SMILES字符串
COc1ccc(cc1)C(NCCOC(=O)NCCCCCCOP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c3ccccc3
InChI
1S/C38H53N4O5P/c1-31(2)42(32(3)4)48(47-29-16-25-39)46-28-15-7-6-14-26-40-37(43)45-30-27-41-38(33-17-10-8-11-18-33,34-19-12-9-13-20-34)35-21-23-36(44-5)24-22-35/h8-13,17-24,31-32,41H,6-7,14-16,26-30H2,1-5H3,(H,40,43)
InChI key
VTFLXOVDKJUHER-UHFFFAOYSA-N
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一般描述
ssH-linker comprises an internal carbamate group attached to the MMT-protected amino group via a short spacer. The carbamate moiety facilitates the cleavage of the MMT group under mildly acidic conditions while increasing the stability of the MMT group during the deprotection of the oligonucleotide with ammonia. The carbamate group also enhances the reactivity of the amino group through a neighbor group effect, and thereby accelerates conjugations to amino reactive modifiers and reporters. The MMT-group of ssH-linker serves as an excellent purification handle after the oligonucleotide synthesis in trityl-on mode, similar to the DMT-group of conventional oligonucleotides. The MMT-group is cleaved under very mild conditions in aqueous acetic acid (10% glacial acetic acid in the water, 20 min. room temp.) Alternatively, the MMT-group can be cleaved on the synthesis instrument with an acidic deblock solution to enable on-support labeling protocols.
法律信息
This product is covered under US Patent Number 7,491,857
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
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