M0199
Mdivi-1
≥98% (HPLC), powder, mitochondrial division DRP inhibitor
别名:
3-(2,4-二氯-5-甲氧基苯）-2,3-二羟基-2-硫基-4（1H）-喹唑啉酮, 3-(2,4-二氯-5-甲氧基苯）-2-硫烷基-4（3H）-喹唑啉酮
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选择尺寸
关于此项目
经验公式（希尔记法）:
C15H10Cl2N2O2S
化学文摘社编号:
分子量:
353.22
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
Mdivi-1, ≥98% (HPLC), powder
质量水平
方案
≥98% (HPLC)
表单
powder
颜色
white to beige
溶解性
DMSO: >20 mg/mL
运输
wet ice
储存温度
−20°C
SMILES字符串
COc1cc(N2C(S)=Nc3ccccc3C2=O)c(Cl)cc1Cl
InChI
1S/C15H10Cl2N2O2S/c1-21-13-7-12(9(16)6-10(13)17)19-14(20)8-4-2-3-5-11(8)18-15(19)22/h2-7H,1H3,(H,18,22)
InChI key
NZJKEVWTYMOYOR-UHFFFAOYSA-N
一般描述
线粒体分裂抑制剂1（Mdivi-1）是喹唑啉酮衍生物，具有细胞渗透性。能穿越血脑屏障，在心、脑缺血再灌注损伤中引发保护功能。
应用
Mdivi-1用于：
- 胚胎胸主动脉A7r5细胞，抑制细胞迁移和增殖
- 研究少突胶质前体细胞（OPC）中线粒体网络重塑和活性氧（ROS）产生
- 诱导肺成纤维细胞的线粒体损伤
生化/生理作用
Mdivi-1是线粒体DRP（发动蛋白相关GTP酶）分裂选择性抑制剂以及线粒体分裂发动蛋白（Dnm1）抑制剂。线粒体融合和分裂在细胞凋亡调节中有很重要的作用。Mdivi-1是线粒体分裂发动蛋白首选抑制剂。基本上，Mdivi-1代表了一系列用于治疗中风，心肌梗塞和神经退行性疾病的药物。
Mdivi-1是线粒体DRP（发动蛋白相关GTP酶）分裂选择性抑制剂；线粒体分裂发动蛋白（Dnm1）抑制剂。
特点和优势
该化合物是细胞凋亡研究的特色产品。点击此处 ，查看更多细胞凋亡精选产品。想要了解有关生物活性小分子在其他研究领域应用的更多信息，请访问sigma.com/discover-bsm。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
To mdivi-1 or not to mdivi-1: Is that the question?
Smith G and Gallo G
Developmental neurobiology, 77(11), 1260-1268 (2017)
Da Zhang et al.
PloS one, 13(5), e0197266-e0197266 (2018-05-17)
Hypoxia-mediated pancreatic beta cell death is one of the main causes of pancreatic beta celldeath, which leads to the loss of functional pancreatic beta cell mass and type 1 diabetes andtype 2 diabetes.However, the molecular mechanisms that control life and
The putative Drp1 inhibitor mdivi-1 is a reversible mitochondrial complex I inhibitor that modulates reactive oxygen species
Bordt EA, et al.
Developmental Cell, 40(6), 583-594 (2017)
Jia Sun et al.
The Journal of endocrinology (2019-01-09)
The molecular signaling mechanisms of Coenzyme Q10 (CoQ10) in diabetic nephropathy (DN) remain poorly understood. We verified that mitochondrial abnormalities, like defective mitophagy, the generation of mitochondrial reactive oxygen species (mtROS) and the reduction of mitochondrial membrane potential, occurred in
K Magalon et al.
Neuropharmacology, 111, 293-303 (2016-09-14)
Multiple sclerosis (MS) is a neurodegenerative disease characterized by episodes of immune attacks and oligodendrocyte death leading to demyelination and progressive functional deficits. New therapeutic strategies are needed to stimulate the spontaneous regenerative process observed in some patients. Spontaneous myelin
商品
Cell cycle phases (G1, S, G2, M) regulate cell growth, DNA replication, and division in proliferating cells.
Apoptosis regulation involves multiple pathways and molecules for cellular homeostasis.
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