M006
丙谷胺 钠盐
solid
别名:
4-苯甲酰氨基-5-二丙氨基-5-氧代戊酸 钠-钾盐, N-苯甲酰基-N′,N′-二丙基-DL-异谷氨酰胺 钠-钾盐
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选择尺寸
关于此项目
经验公式（希尔记法）:
C18H25N2NaO4
化学文摘社编号:
分子量:
356.39
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
产品名称
丙谷胺 钠盐, solid
InChI
1S/C18H26N2O4.Na/c1-3-12-20(13-4-2)18(24)15(10-11-16(21)22)19-17(23)14-8-6-5-7-9-14;/h5-9,15H,3-4,10-13H2,1-2H3,(H,19,23)(H,21,22);/q;+1/p-1
SMILES string
[Na+].CCCN(CCC)C(=O)C(CCC([O-])=O)NC(=O)c1ccccc1
InChI key
UFMWGCINVOIJSO-UHFFFAOYSA-M
form
solid
color
white
solubility
H2O: soluble
Quality Level
Gene Information
human ... CCK(885), CCKAR(886), CCKBR(887)
mouse ... CCK(12424)
rat ... CCK(25298)
Application
丙谷胺钠盐已被用于研究丙谷胺对欧洲鲈鱼，舌齿鲈中宏营养物质选择的影响。
Biochem/physiol Actions
CCK拮抗剂；选择性地阻断CNS效应。
丙谷胺钠盐是一种非肽胆囊收缩素受体拮抗剂，其对CCKA亚型具有更高的选择性。它可有选择地阻止中枢神经系统的影响。丙谷胺钠盐具有口服活性。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
The cholecystokinin antagonist, proglumide, increases food intake in the rat
G.Shillabeer and J. Davidson
Regulatory Peptides (1984)
J V Menani et al.
The American journal of physiology, 275(5 Pt 2), R1431-R1437 (1998-10-29)
The present study investigated the effects of bilateral injections of the nonselective CCK receptor antagonist proglumide or CCK-8 into the lateral parabrachial nuclei (LPBN) on the ingestion of 0.3 M NaCl and water induced by intracerebroventricular injection of ANG II
Role of cholecystokinin and its antagonist proglumide on macronutrient selection in European sea bass Dicentrarchus labrax, L.
V. C. Rubio
Physiology & Behavior (2008)
E S Corp et al.
Physiology & behavior, 61(6), 823-827 (1997-06-01)
Cholecystokinin (CCK) receptors are classified as two subtypes, designated CCK(A) and CCK(B), and both subtypes are found in brain and peripheral tissues of rats. CCK-8 has been shown to act peripherally to reduce meal size, and this satiating action can
James M Hill et al.
Science translational medicine, 6(265), 265ra169-265ra169 (2014-12-05)
Herpesviruses are highly prevalent and maintain lifelong latent reservoirs, thus posing challenges to the control of herpetic disease despite the availability of antiviral pharmaceuticals that target viral DNA replication. The initiation of herpes simplex virus infection and reactivation from latency
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