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安全信息

LO4100

Sigma-Aldrich

LOPAC®1280 - Small Scale

别名:

药理活性化合物库-小规模

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About This Item

EC 号:
200-664-3
UNSPSC代码:
12352200
NACRES:
NA.77

形式

liquid

质量水平

100

运输

dry ice

储存温度

−20°C

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一般描述

Compounds are arranged in 96-well format in 16 racks of 80, one compound per well (25 μl at 10 mM in DMSO in archival storage racks).
LOPAC® 1280 is an extensively used library of pharmacologically active compounds. This library includes 1,280 marketed drugs, failed development candidates, and small molecules with well-characterized activities. LOPAC 1280 spans a broad molecular weight range, exhibits multiple mechanisms of action and interacts with a variety of biological receptors.

应用

LOPAC® 1280 - Small Scale has been used:
  • in sprouting assay to screen potential lymphangiogenic inhibitors and the signaling pathways involved in lymphangiogenesis
  • for identification of neuroactive compounds by measuring spontaneous activity within single zebrafish embryos by high-content screening assay
  • for high-throughput Screen for ectonucleoside triphosphate diphosphohydrolase-1 (ENTPD1; also known as CD39) and ecto-5′-nucleotidase (CD73) inhibitors

特点和优势

包括细胞信号& 神经科学领域中最新的类药物分子 ：

  • 细胞凋亡
  • G 蛋白 & 环核苷酸
  • 基因调控 & 表达
  • 离子通道
  • 脂质信号
  • 多重耐药性
  • 神经传递
  • 磷酸化
提供 SDFile 来构建包含以下内容的数据库：
  • 结构
  • 主要名称
  • 次要名称
  • 药理活性
  • 货号
  • 管架位置

其他说明

For sale inside of the U.S. only. Customers outside the US should refer to Product Code LO4200.

法律信息

LOPAC is a registered trademark of Merck KGaA, Darmstadt, Germany

警示用语：

Danger

危险分类

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1A - Eye Dam. 1 - Lact. - Muta. 1B - Repr. 1A - Resp. Sens. 1 - Skin Corr. 1B - Skin Sens. 1 - STOT RE 2 - STOT SE 2

WGK

WGK 3

闪点(°F)

188.6 °F

闪点(°C)

87 °C

法规信息

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分析证书(COA)

输入产品批号来搜索 分析证书(COA) 。批号可以在产品标签上"批“ （Lot或Batch）字后找到。

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

    There are several ways to find pricing and availability for our products. Once you log onto our website, you will find the price and availability displayed on the product detail page. You can contact any of our Customer Sales and Service offices to receive a quote.  USA customers:  1-800-325-3010 or view local office numbers.

  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What is the difference between the LOPAC1280 Products LO4100 and LO4200?

    These 2 products are the same. LO4100 is the US version versus LO4200 is the International version.

  6. What is the difference between the LOPAC®,1280 product numbers LO4100 and LO1280?

    The compound per well in LO4100 is 25 ul at 10mM in DMSO versus 250 ul in the product LO1280

  7. Can I get a list of CAS numbers of the drugs sent with LOPAC 1280 - Small Scale Products LO4100 and LO4200?

    There is no CAS number list available.

  8. Is the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD shipped with the product?

    Yes, the CD is shipped with the product. If you do not receive it you should contact Sigma-Aldrich Technical Services at techserv@sial.com or 1800-325-5832.

  9. What is on the LOPAC 1280 - Small Scale Products LO4100 and LO4200 CD?

    The CD contains the SDFile - provided to construct a database containing structure, primary name, secondary, Pharmacological Activity. Product number and Rack position.

  10. Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200 approved for therapeutic use?

    Although there are FDA approved drugs in the set, we market them based on their research application and not necessarily their therapeutic indications. All of the information we have is included on the CD that is received with the library. We do not include information from the Physician's Desk Reference.

  11. Are the LOPAC 1280 - Small Scale Products LO4100 and LO4200  US approved?

    About 30% of the collection is made up of drugs approved for use in the US.

  12. Where can I find preparation instruction, storage and stability of the LOPAC 1280 - Small Scale Products LO4100 and LO4200?

    The information is available in the datasheet of a similar product LO1280.

  13. My question is not addressed here, how can I contact Technical Service for assistance?

    Ask a Scientist here.

Sara M Vliet et al.
Toxicology and applied pharmacology, 329, 241-248 (2017-06-18)
Spontaneous activity represents an early, primitive form of motor activity within zebrafish embryos, providing a potential readout for identification of neuroactive compounds. However, despite use as an endpoint in chemical screens around the world, the predictive power and limitations of
Roland E Kälin et al.
Blood, 114(5), 1110-1122 (2009-05-30)
Angiogenesis and lymphangiogenesis are essential for organogenesis but also play important roles in tissue regeneration, chronic inflammation, and tumor progression. Here we applied in vivo forward chemical genetics to identify novel compounds and biologic mechanisms involved in (lymph)angiogenesis in Xenopus
Miao Xu et al.
Nature medicine, 22(10), 1101-1107 (2016-08-30)
In response to the current global health emergency posed by the Zika virus (ZIKV) outbreak and its link to microcephaly and other neurological conditions, we performed a drug repurposing screen of ∼6,000 compounds that included approved drugs, clinical trial drug
Meera Kumar et al.
SLAS discovery : advancing life sciences R & D, 25(3), 320-326 (2019-12-24)
Production of adenosine in the extracellular tumor microenvironment elicits strong immunosuppression and is associated with tumor progression. Thus, targeting adenosine-generating ectonucleotidases is a potential strategy to stimulate and prolong antitumor immunity. Because the reaction products of ectonucleotidases differ by a
Martin Michael Peter Schulz et al.
Proceedings of the National Academy of Sciences of the United States of America, 109(40), E2665-E2674 (2012-09-06)
Lymphangiogenesis plays an important role in promoting cancer metastasis to sentinel lymph nodes and beyond and also promotes organ transplant rejection. We used human lymphatic endothelial cells to establish a reliable three-dimensional lymphangiogenic sprouting assay with automated image acquisition and
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LOPAC®1280 Small Molecules Screening

Explore compound library screening options with our Pharmacologically Active Compounds portfolio.

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